64排螺旋CT与血清肿瘤标志物联合检测在肺癌诊断中的价值

THE VALUE OF 64-SLICE SPIRAL CT COMBINED WITH SERUM TUMOR MARKERS FOR THE DIAGNOSIS OF LUNG CANCER

目的探讨64排螺旋CT与血清肿瘤标志物联合检测在肺癌诊断中的价值,旨在为肺癌的临床诊断提供参考。方法选取55例肺癌患者(观察组)和50例肺部良性病变者(对照组),分别采用64排螺旋CT扫描、检测血清肿瘤标志物如癌胚抗原(CEA)、细胞角质素片段抗原21-1(CYFRA21-1)及神经元特异性烯醇化酶(NSE)等指标,分析血清肿瘤标志物、CT单独检测以及联合检测的敏感性和特异性。结果观察组CEA、CYFRA21-1及NSE水平均高于对照组,且二组比较差异有统计学意义(P<0.05);血清肿瘤标志物与CT扫描联合诊断的特异性(92.2%)和敏感性(90.2%)均明显提高。结论血清肿瘤标志物与CT扫描联合用于肺癌的诊断,可进一步提高肺癌诊断的准确性、特异性及敏感性,对于肺癌的临床诊断具有重要的应用价值。

Objective To evaluate the value of 64-slice spiral CT combined with the detection of ser-um tumor markers for the diagnosis of lung cancer, to provide reference for clinical diagnosis of lung cancer. Methods Totally 55 cases of lung cancer patients （the study group ） and 50 cases of benign lung lesions （the control group ） were collected for 64 - slice spiral CT scanning, and the serum tumor markers such as carcinoembryonic antigen （CEA）, cell keratin fragments antigen 21 - 1 （CY-FRA 21 - 1） and neuron-specific enolase （NSE） were detected, respectively. The detection sensitivi-ty and specificity were compared. Results The CEA, CYFRA 21 - 1 and NSE levels of the study group were higher than those of the control group（P〈0.05）. The diagnostic specificity （92.2%） and sensitivity （90.2%） of 64-slice spiral CT combined with the detection of serum tumor markers were both improved. Conclusion 64-slice spiral CT combined with the detection of serum tumor markers for the diagnosis of lung cancer can further improve the accuracy, the sensitivity and specificity for the diagnosis of lung cancer, which has important application value.