IL-10基因3575T>A位点多态性和淋巴瘤易感性的荟萃分析

Interleukin-10 3575T > A polymorphism and lymphoma risk: a meta-analysis

目的：评价IL-10基因3575 T〉A位点多态性与淋巴瘤易感性的关系。 方法：通过检索CNKI和PubMed数据库，获取相关文献，用固定效应模型或随机效应模型进行数据合并。发表偏移的评估用Begg′s漏斗图和Egger′s检验。 结果：共纳入7篇文献，包括6 668例患者和8 175例对照；对所有入选文献数据进行荟萃（meta）分析，等位基因模型（A vs T：OR=1.145，95%CI=1.034－1.268，I2=70.0%）和显性基因模型（AT＋AA vs TT：OR=1.076，95%CI=1.007－1.148,I2=30.3%）的统计结果显示IL-10基因3575 T〉A位点A等位基因可能增加淋巴瘤的发病风险；按淋巴瘤类型和样本大小进行分层分析，非霍奇金淋巴瘤（NHL）的两种基因模型（A vs T；AT＋AA vs TT）以及大样本的3种基因模型（A vs T，AA vs TT， AT＋AA vs TT）的统计结果均显示，IL-10基因3575T〉A位点A等位基因可能增加淋巴瘤的发病风险。 结论：IL-10 3575 T〉A基因多态性可能与淋巴瘤的易感性相关。

Objective：To evaluate the association between interleukin-10 3575 T〉A （IL-10 3575） polymorphism and lymphoma risk. Methods：Meta-analysis was conducted to estimate the association. The relevant medical publications were obtained by searching Chinese National Knowledge Infrastructure （CNKI） and PubMed database. The data were merged by fixed effect model or random effect model. Publication bias was evaluated by using the Begg′s funnel plot and Egger′s test. Results：Seven eligible reports were identified, concerning 6 668 lymphoma cases and 8 175 controls. The results of the overall meta-analysis showed that the IL-10 3575A allele was associated with increased risk of lymphoma. The results of the two genetic models were allele genetic model ［A vs T： OR=1.145, 95%confidence interval （CI）：1.034 to 1.268，I2=70.0%］ and recessive genetic mode （AT＋AA vs TT： OR=1.076, 95%CI： 1.007 to 1.148, I2=30.3%）. In the stratification analysis of lymphoma type and sample size subgroup, the results of two genetic model of non-Hodgkin lymphoma （NHL） （A vs T, AT＋AA vs TT） and three genetic models of large sample （A vs T, AA vs TT, AT＋AA vs TT） showed that the IL-10 3575A allele was associated with elevated lymphoma risk. Conclusion ：The polymorphism at IL-10 3575 T〉A allele may be associated with increased risk of lymphoma.