中医药对中晚期结直肠癌患者化疗疗效影响的Meta分析

Clinical Analysis of Herbal Medicines plus Chemotherapy for Advanced Colorectal Cancer Treatment:A Meta-analysis

目的:探讨中医药对中晚期结直肠癌患者化疗疗效的影响。方法:计算机检索MEDLINE、EMBASE、Cochrane、CNKI、维普、万方等中英文数据库中有关中医药联合化疗治疗中晚期结直肠癌的随机对照实验,按照排除纳入标准筛选后使用STATA 12.0软件进行Meta分析。结果:19项RCT共1280例中晚期结直肠癌患者纳入本项研究中,Meta分析显示,中医药治疗联合化疗组的CR+PR总体比例比单纯化疗组高,OR(95%CI)值为1.67(1.32,2.12),差异有统计学意义。Begg's检验显示本项Meta分析存在不影响最终结论的发表偏倚,而敏感性分析也显示本研究结论具有较强的稳定性。结论:与单纯化疗治疗相比,中医药联合化疗治疗中晚期结直肠癌可以获得更好的临床缓解效果。

Objective： To investigate the influence of herbal medicines plus chemotherapy compared with chemotherapy alone for the treatment of advanced colorectal cancer. Methods： The search strategy included MEDLINE, EMBASE, Cochrane, CNKI, Vipbrowser and Wanfang database. All clinical trials compared herbal medicines plus chemotherapy with chemotherapy alone were included. Meta-analysis was performed by using STATA 12.0. Results： There were 19 studies with 1280 cases in- cluded in immediate result of treatment evaluation. Compared with chemotherapy alone, herbal medicines plus chemotherapy achieved a higher rate of CR＋PR, and the difference is statistically significant [OR （95%C/）=1.67 （1.32, 2.12）, P〈O.001]. Begg＇s funnel plot was performed and no publication bias was detected. Sensitivity analysis also indicated that our results were statistically robust. Conclusion： Compared with chemotherapy alone, herbal medicines plus chemotherapy was generally better for treatment of advanced colorectal cancer patients.