孕24～28周GDM孕妇部分急性时相反应蛋白和胰岛素功能的研究

Study on partial acute phase reaction proteins and insulin function in GDM pregnant women during 24-28 gestational weeks

目的：研究妊娠妇女部分急性时相反应蛋白与妊娠期糖尿病的相关性。方法：采用病例对照研究方法，按年龄、孕周、BMI等匹配妊娠期糖尿病患者（GDM）36例和健康妊娠妇女（HPW）44例，分析其孕24～28周血浆超敏c反应蛋白（hs—CRP）、铜蓝蛋白（CER）、转铁蛋白（TRF）和胰岛素功能的差异。结果：与健康孕妇组相比，GDM孕妇组空腹血糖、胰岛素、胰岛素抵抗指数和hs—CRP均显著升高（P〈0．01）；hs—CRP与胰岛素抵抗指数（HOMA—IR）呈正相关（r=0．372，P=0．002）。而CER和TRF与胰岛素功能无显著相关性。结论：GDM孕妇血浆hs—CRP升高与胰岛素功能下降呈显著相关，提示血浆hs—CRP可能与妊娠期糖尿病的发生发展有关。

Objective： To research the correlation between partial acute phase reaction proteins （APRP） and gestational diabetes mellitus （GDM） in pregnant women. Methods ： A case - control study was conducted, 36 GDM pregnant women and 44 healthy pregnant women （HPW） were paired according to age, gestational week, and BMI; the differences of plasma high - sensitivity C - reactive protein （hs - CRP）, ceruloplasmin （ CER）, transferrin （TRF）, and insulin function during 24 - 28 gestational weeks were analyzed. Results： Compared with HPW group, fasting blood glucose, insulin, insulin resistance index （HOMA -IR）, and hs -CRP in GDM group increased significantly （ P 〈 0. 01 ） ; there was a positive correlation between hs - CRP and HOMA - IR （ r = 0. 372, P = 0. 002 ） ; but there was no a significant correlation between CER, TRF and insulin function. Conclusion： Increase of plasma hs - CRP is significantly correlated with in- sulin function decline in GDM pregnant women, which indicates that plasma hs - CRP might be correlated with occurrence and development of GDM.