摘要
目的:分析宫颈脱落细胞学检查结果为不明确意义非典型鳞状上皮细胞(ASCUS)患者,在不同亚型人乳头瘤病毒(HPV)感染情况下的组织病理学结果,为ASCUS患者临床处理方法的选择提供依据。方法:大连市相关宫颈癌筛查项目中,宫颈脱落细胞学检查结果为ASCUS,并同意接受HPV分型检测及阴道镜检查的448例女性为研究对象,分析ASCUS患者的HPV感染亚型与组织病理学结果之间的相关性。结果:448例ASCUS患者中HPV阳性251例,阳性率为56.03%,HPV阳性组的宫颈癌及其癌前病变患病率(29.08%)高于HPV阴性组(4.06%);组织病理学诊断为宫颈上皮内瘤变(CIN)者80例,宫颈浸润癌(SCC)1例,检出率为18.08%。高危HPV16、58、52、33、31和18型感染者宫颈癌及癌前病变的检出率依次为:57.14%(28/49)、34.78%(8/23)、31.82%(7/22)、18.75%(3/16)、44.44%(4/9)、42.86%(3/7)。结论:应通过HPV分型检测对ASCUS患者群进行分流管理,以提高宫颈癌及其癌前病变的诊断率。
Objective: To analyze the histopathological results of the patients with different subtypes of human papillomavirus (HPV) diagnosed as atypical squamous ceils of undetermined significance (ASCUS) after cervical exfoliocytological examination, provide a basis for choosing clinical treatment of ASCUS. Methods: A total of 440 women diagnosed as ASCUS after cervical exfoliocytological exami- nation and receiving HPV genotyping and colposcopy in Dalian cervical cancer screening project were selected as study objects, the correla- tion between HPV subtypes of ASCUS patients with HPV infection and histopathological results was analyzed. Results : Among 448 ASCUS patients, 251 patients were found with positive HPV, the positive rate of HPV was 56.03%, the incidence rate of cervical cancer and cervi- cal precancerous lesion in positive HPV group was 29. 08%, which was higher than that in negative HPV group (4. 06% ) ; 80 patients were diagnosed as cervical intraepithelial neoplasia (CIN) by histopathological examination, one patient was diagnosed as invasive cervical cancer, the detection rate was 18.08% ; the detection rates of high risk HPV16, 58, 52, 33, 31, 18 were 57.14% (28/49), 34. 78% (8/ 23), 31.82% (7/22), 18.75% (3/16), 44.44% (4/9), and 42. 86% (3/7), respectively. Conclusion: ASCUS patients can be separated and managed through HPV genotyping to improve the diagnostic rates of cervical cancer and cervical precancerous lesion.
出处
《中国妇幼保健》
CAS
北大核心
2014年第10期1498-1501,共4页
Maternal and Child Health Care of China
基金
辽宁省大连市卫生局科研项目〔2010153号
序号47〕