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持续输注小剂量右美托咪定对瑞芬太尼全凭静脉麻醉后痛觉过敏的影响 被引量：8

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摘要 瑞芬太尼以其优良药代动力学特性,已成为临床上常用的麻醉性镇痛药.但大剂量使用后,会出现痛觉过敏的现象[1,2].表现为难以控制的疼痛、寒颤、躁动等不良反应,还可能诱发心脑血管意外,危及围麻醉期安全.盐酸右美托咪定（dexmedetomidine,Dex）是高选择性α2肾上腺素受体激动药,具有抗交感神经活性并能产生一定的镇静、镇痛作用.本研究观察在创伤较大的开胸肺叶切除术中持续输注小剂量的右美托咪定,对大剂量使用瑞芬太尼麻醉苏醒期痛觉过敏的影响,为右美托咪定在临床应用提供一定的理论依据.
作者 杨静远 刘继鑫 王东昕
机构地区 吉林省肿瘤医院麻醉科
出处 《中国实验诊断学》 2014年第3期469-471,共3页 Chinese Journal of Laboratory Diagnosis
关键词 痛觉过敏 瑞芬太尼 持续输注 小剂量 α2肾上腺素受体激动药 麻醉后 盐酸右美托咪定 静脉
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献10

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二级参考文献8

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共引文献290

同被引文献72

  • 1王庚,吴新民.瑞芬太尼复合麻醉患者术后急性阿片类药物耐受的发生[J].中华麻醉学杂志,2007,27(5):389-392. 被引量：88
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二级引证文献50

中国实验诊断学
2014年 第3期

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