酒精性肝炎患者不同治疗方案的疗效观察

Analysis of different protocols in treatment of alcoholic hepatitis

目的：探讨不同治疗方案对酒精性肝炎患者的治疗效果。方法选择酒精性肝炎患者128例，随机分为研究组（48例）、对照1组（40例）及对照2组（40例），研究组给予异甘草酸镁注射液150 mg，1次/d静脉滴注；对照1组予以还原型谷胱甘肽1.2 g，1次/d静脉滴注；对照2组予以硫普罗宁0.2 g，1次/d静脉滴注，治疗时间2周~3周。结果研究组腹胀、纳差、乏力、黄疸、肝脏肿大和压痛减轻率均高于对照1组、对照2组（均P〈0.05）。研究组治疗后丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、谷氨酰转肽酶（GGT）、总胆红素的水平均低于对照1组、对照2组（P〈0.01）。结论异甘草酸镁对于控制酒精性肝炎炎症活动有显著作用，且优于还原型谷胱甘肽、硫普罗宁。

Objective To analyse and compare the effectiveness of different protocols on alcoholic hepatitis. Methods 128 patients were randomly divided into treatment group（n=48）、control group 1（n=40） and control group 2 （n=40）.Patients in the treatment group were given magnesium isoglycyrrhizinate 150 mg once every day. Patients in the control group 1 were given reduced glutathione 1.2 g once every day. Patients in the control group 2 were given tiopronin 0.2g once everyday.The Course was 2~3 weeks. Results Patients in three groups showed therapeutic effect with statistical significance（P〈0.05）.After treatment.the degree of biochemieal indicators declined significantly inthe treatment group than that of the control groups（P〈0.01）.Conclusion The result shows that magnesium isoglycyrrhizinate、reduced glutathione and tiopronin are effective drugs for controlling inffanunation activity of thealcoholic hepatitis and magnesium isoglycyrrhizinate is a more effective and safer agent than reduced glutathione and tiopronin.