幽门螺杆菌感染与慢性胃炎及消化性溃疡的临床分析

Clinical analysis of helicobacter pylori infection relation to chronic gastritis and peptic ulcer

目的探讨慢性胃炎(CG)和消化性溃疡(PU)与幽门螺杆菌(Hp)感染的关系。方法将有上腹隐痛、饱胀不适、反酸、嗳气等上消化道症状,经胃镜诊断为慢性胃炎的252例、消化性溃疡的80例患者作为观察组;将无消化系统症状,正常体检做胃镜检查者102例作为对照组。2组患者分别在病变部位、溃疡周围及胃窦部处取活组织,用苏木素-伊红(HE)染色确定活动期。经改良Giemsa染色查Hp。结果 CG及PU患者Hp感染总检出率(61.5%)与对照组Hp总检出率(26.5%)相比,有显著性差异(P<0.01)。活动期消化性溃疡Hp检出率(94.0%)高于非活动期消化性溃疡(38.5%),2组有显著性差异(P<0.01)。结论 CG和PU的发生与幽门螺杆菌(Hp)感染有密切关系。

Objective To investigate the relationship of chronic gastritis （CG）and peptic ulcer（PU）and Helicobacter pylori （Hp）infection. Methods Gastros-copy results from 2009.3 to 2012.12 in our hospital were statistically. The patients with Upper abdominal pain,bloating,belching,acid regurgitation, discomfort,gastrointestinal symptoms, and endoscopic diagnosis peptic ulcer of 252 cases,patients with chronic gastritis of 80 cases.102 cases of the control group, no symptoms of the digestive system, do gastroscope in normal examination. The two groups of patients take living tissue at the lesion site,around the ulcer and gastric antrum respectively,with hematoxylin and eosin（HE） staining to determine the activity period. After improved Giemsa stain Hp. Results CG and PU and Hp infection detection rate （61.5%）and the control group,the detection rate of Hp （26.5%）,two groups had significant difference （P〈0.01）.The detection rate of active peptic ulcer Hp（94%） was higher than that of active peptic ulcer（38.5%）,the two groups had significant difference （P〈0.01）.Conclusion CG and PU to Helicobacter pylori （Hp） infection has close relationship.