幽门螺杆菌感染与胃食管反流病病程相关性研究

The correlation study between helicobacter pylori infection and gastroesophageal reflux disease progression

目的：研究患者幽门螺杆菌（Hp）感染状况及其与胃食管反流病（GERD）的相关性。方法抽取该院健康体检及消化内科门诊患者进行问卷调查并进行14C呼吸实验检测 Hp感染，调查GERD 患病情况，分析 Hp感染与GERD的关系。结果220例健康体检者中，Hp阳性108例。所有GERD患者中有238例为阳性，其中，0～≤3个月、3～≤6个月，＞6个月GERD发病者Hp阳性率分别为47．8％、44．1％和27．5％。GERD者6个月以上发病者阳性率低于健康者和小于或等于6个月者，差异有统计学意义（P＜0．01）。健康体检Hp阳性者给予Hp根除治疗，强调自我管理行为优化，4周后复查，根除率达到100％，服药过程中无明显不良反应。GERD Hp阳性者常规抗酸和增加胃动力治疗2周，症状缓解后加入 Hp根除治疗，同样强调自我管理行为优化，期间没有出现症状加重者。结论 GERD不同阶段的患者Hp感染程度不同，症状严重、反复就诊患者 Hp感染率低，健康阳性体检者Hp根除后未出现GERD的相关病例。

Objective To study the status of helicobacter pylori （Hp） infection and its correlation with gastroesophageal reflux disease（GERD） .Methods The Physical examination and digestive internal medicine outpatients was chosen for the detailed ques-tionnaire and 14C breath test detection of Hp infection ,investigation of GERD prevalence ,analyzed the relations between Hp infec-tion and GERD sick .Results In 220 cases of healthy check-up person ,Hp positive in 108 cases .There were 238 cases of Hp posi-tive in all GERD patients ,the positive rates of Hp infection for 0 - ≤3 months ,3 - ≤6 months and ＆gt;6 months GERD patients were 47 .8% 、44 .1% and 27 .5% ,respectively .The positive rates of Hp infection for ＆gt;6 months were significant lower than other groups （P＆lt;0 .01） .Health people who check -up with Hp positive were given Hp eradication therapy ,and emphasized the optimi-zation of self -management behavior ,4 weeks after the review ,eradication rate was 100% ,no obvious adverse reaction in the process of taking the medicine .GERD Hp was given conventional acid and increase the stomach power for 2 weeks ,symptoms after joining Hp eradication therapy ,also emphasized the self - management behavior optimization ,without symptoms worsen . Conclusion Hp infection in patients with different degrees at different stages of GERD .Severe symptoms ,repeated visits patients with low Hp infection rate .There is no GERD related cases after Hp eradication in positive health check-up person .