N-cadherin和vimentin在直肠腺癌中的表达及其临床意义

The expression of N-cadherin and vimentin in rectum adenocarcinoma and their clinical value

目的探讨N钙黏蛋白(neuronal cadherin,N-cadherin)和波形蛋白(vimentin)在原发性直肠腺癌中的表达及其临床意义。方法选择手术切除并经病理证实的58例原发性直肠腺癌组织和距肿瘤5cm以上的正常直肠黏膜组织,采用免疫组织化学SP法检测组织中N-cadherin和vimentin的表达并与临床资料进行相关性分析。结果直肠腺癌组织中N-cadherin和vimentin阳性表达率[53.4%(31/58)、46.6%(27/58)]明显高于正常直肠黏膜组织[3.4%(2/58)、1.7%(1/58)](P<0.01);N-cadherin和vimentin的阳性率与肿瘤浸润深度、淋巴结转移、远处转移和TNM分期呈正相关(P<0.05),与肿瘤分化程度无相关性(P>0.05)。结论 N-cadherin和vimentin的表达与原发性直肠腺癌的转移密切相关,检测N-cadherin和vimentin的表达可作为判断直肠腺癌转移和预后的指标之一。

Objective To observe the expression of neuronal cadherin （N-cadherin） and vimentin in primary rectum adenocarci-noma tissues and their clinical value .Methods 58 cases of primary rectum adenocarcinoma tissues after surgical resection and con-firmed by pathology ,and normal rectum tissues that at lest 5 cm away from the tumor were selected .The immunohistochemical SP method was used to detect the expression of N-cadherin and vimentin and analyzed their correlation .Results In rectum adenocarci-noma tissues ,the positive expression rate of N-cadherin and vimentin[53 .4% （31/58） ,46 .6% （27/58）]were significantly higher than those of in normal rectum mucosa tissues[3 .4% （2/58） ,1 .7% （1/58）] ,（P＆lt;0 .01） .The expressions of N-cadherin and vimen-tin were positively correlated with the depth of cancer invasion ,lymph node metastasis ,distant metastasis and tumor-node-metasta-sis（TNM） stage（P＆lt;0 .05） ,but without correlated with the tumor cell differentiation（P＆gt;0 .05） .Conclusion N-cadherin and vim-entin have close relationships with metastasis of rectum adenocarcinoma ,to detect the expressions of N-cadherin and vimentin is of a effective method to judge the metastasis and prognosis of rectum adenocarcinoma .