线粒体在心肌保护中作用的研究进展

Research progress on the role of mitochondria in myocardial protection

线粒体是细胞内重要的细胞器,三羧酸循环、电子传递和氧化磷酸化均在线粒体中进行,是细胞中心代谢途径的核心。在生理情况下,其是细胞的能量加工器,维持细胞的正常能量代谢和存活;在缺血再灌注情况下线粒体功能发生紊乱,转而促进细胞的坏死和凋亡。对心肌损伤机制的研究表明,线粒体的功能损害是导致缺血再灌注心肌不可逆损伤的重要原因之一。所以,线粒体保护成为解决心肌损伤的重要途径之一。大量研究表明,线粒体ATP敏感性钾通道、线粒体通透性转换孔、线粒体型硫氧还蛋白、线粒体钙激活钾通道、缝隙连接蛋白43在线粒体的心肌保护中发挥着重要作用。本文就近年来线粒体在心肌保护中的作用研究进展做一综述。

Mitochondria is important intracellular organelle, Krebs cycle, electron transport and oxidative phosphorylation are carried out in mitochondria, which is the center of metabolic pathways. In physiological conditions, mitochondria is the cell′s energy processing device, maintaining the energy metabolism and survival of normal cell; In the case of ischemia reperfusion, mitoehondrial functions are disorder and promote cell necrosis and apoptosis. Studies on the mechanism of myocardial injury suggest that mitochondrial dysfunction is one of the important reasons leading to irreversible myocardial ischemia reperfusion injury. There fore, the protection of mitochondria has become an important way to solve myocardial injury. Numerous studies show that mitochondrial ATP - sensitive potassium channels, mitochondrial permeability transition pore, mitochondrial thioredoxin, mitoehondrial cal- cium - activated potassium channels and connexin 43 play an important role in mitochondrial cardioprotection. The review focuses on the research progress of the role of mitochondria in myocardial protection.