G蛋白偶联受体56在喉癌组织中的表达及其意义

Expression and its significance of G protein-coupled receptor 56 in laryngeal carcinoma

目的探讨G蛋白偶联受体56(GPR56)在喉癌发生发展中的作用。方法应用免疫组织化学检测54例声门型喉癌组织(喉癌组)及23例正常声门区喉组织(正常组)中GPR56的表达,并分析其与喉癌病理特征的关系。结果喉癌组GPR56的表达的累积光密度值(IOD)为4806.0(1414.1,13 257.0),显著高于正常组的428.7(26.4,3266.3)(Z=-4.936,P=0.000);在喉癌组中,GPR56的表达与病理分级、临床分期及有无颈淋巴结转移密切相关(P<0.05)。结论在喉癌组织中GPR56的高表达可能促进喉癌的发生,GPR56的特异性配体有望成为治疗喉癌的新药物。

Objective To investigate the role of GPR56 in the development of laryngeal carcinoma.Methods The expression of GPR56 in 54 cases of glottic laryngeal carcinoma and 23 cases of normal glottic laryngeal tissues was detected by immunohistochemistry,and the relationship between GPR56 and the pathology charateristics of laryngeal carcinoma were also analyzed.Results The expression IOD of GPR56 in the laryngeal carcinoma group of 4806.0 （1414.1,1 3257.0） was significantly higher than that in the normal group of 428.7 （26.4,3266.3） （Z =-4.936,P =0.000）.In the laryngeal carcinoma group,the expression of GPR56 was closely related to histological grade,clinical stage and cervi cal lymph node metastasis （P ＜ 0.05）.Conclusion High expression of GPR56 may contribute to the occurrence of laryngeal carcinoma.GPR56 specifical ligand is expected to become a new drug for the treatment for laryngeal carcinoma.