血管性痴呆嗅觉功能损害的功能MRI研究

Olfactory defi cit detected by fMRI in vascular dementia patients

目的采用嗅觉功能MRI评价血管性痴呆(vascular dementia,VaD)患者的嗅觉功能损害情况。材料与方法 15例正常老年人(NC)和12例VaD患者进行MMSE、MOCA、CDR及Hachinski缺血指数量表(HIS)评分,采用西门子3.0 T MR扫描仪、32通道头线圈行嗅觉fMRI扫描,采用Matlab 7.11.0及SPM 8软件处理数据,NC和VaD两组进行独立样本t检验分析。结果 NC和VaD两组之间组分析结果显示,NC组(28簇,共1486个激活体素)激活明显多于VaD组(13簇,共149个激活体素),激活区域主要位于额叶、颞叶及中央前回等区域。结论 VaD患者存在嗅觉损害,嗅觉fMRI可以评价VaD患者的嗅觉功能,对进一步嗅觉损害的神经退行性疾病研究具有重要价值。

Objective：The olfactory functional MRI （fMRI） was used to investigate the olfactory deficiency in the vascular dementia （VaD）. Materials and Methods：15 normal elderly people （NC group） and 12 VaD （VaD group） patients underwent MMSE, MOCA, CDR and Hachinsk grades. All subjects were scanned by Siemens 3.0 T MRI scanner, with 32 channel head coil, all olfactory fMRI data were processed with 64 bit Matlab 7.11.0 and SPM8 softwares. The independent samples t-test was used to analyze these two groups. Results：Inter-group analysis between two samples showed that the activated voxels in the whole brain of NC group were signiifcantly higher than the VaD group, the activated area was mainly located in the frontal lobe, temporal lobe and the medial frontal gyrus. Conclusion：The VaD patients also suffered olfactory deifcit, the olfactory fMRI can evaluate the olfactory function of VaD patients, which is a potential method to the study of the neurodegenerative diseases with olfactory deifcit.