骨保护素/核因子-κB受体活化因子配体/核因子-κB受体活化因子信号通路与骨质疏松的研究进展

Stress Sensitive Signal Pathway Osteoprotegerin/Receptor Activator of Nuclear Factor-κB ligand/Receptor Activator of Nuclear Factor-κB and Osteoporosis(review)

运动对骨质疏松症有积极作用,但其治疗的分子生物学机制仍未清楚。骨保护素/核因子-κB受体活化因子配体/核因子-κB受体活化因子(OPG/RANKL/RANK)信号通路的发现,有助于骨质疏松症的治疗。机械应力可以调节OPG/RANKL/RANK信号通路,参与预防和治疗骨质疏松进程。本文就应力敏感信号通路OPG/RANKL/RANK与骨质疏松的关系进行综述。

Exercise is benefic for osteoporosis, without clear molecular biology mechanism. The osteoprotegerin/receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factor-κB （OPG/RANKL/RANK） signal pathway contributes to osteoporosis, which can be mediated by mechanical force. Research progress on osteoporosis and the stress sensitive signal pathway OPG/RANKL/RANK were reviewed in this paper.