β-七叶皂苷钠对重型脑损伤患者血清肿瘤坏死因子-α的影响

Effect of β- aescine Sodium on Tumor Necrosis Factor α in Severe Traumatic Brain Injury

目的研究β-七叶皂苷钠对重型脑损伤患者血清肿瘤坏死因子-α(TNF-α)的影响及其临床意义。方法 60例重型脑损伤患者分为治疗组和对照组各30例,对照组给予神经外科常规治疗,治疗组在常规治疗基础上给予β-七叶皂苷钠。分别于治疗前,治疗后第1、2、3、5、7天测定血清TNF-α,于治疗3个月后进行格拉斯哥结局量表(GOS)评分。结果治疗3 d后,治疗组血清TNF-α较对照组下降(P<0.05);治疗3个月后,治疗组GOS评分优于对照组(P<0.05)。结论β-七叶皂苷钠是治疗重型脑损伤的有效手段之一,血清TNF-α的动态变化能够预测治疗结局。

Objective To study the effect ofβ-aescine sodium on tumor necrosis factorα（TNF-α） in patient with severe traumatic brain injury and the clinical significance. Methods 60 patients with severe traumatic brain injury were divided equally into control group （n=30） and treatment group （n=30）, who accepted routine therapy and furtherβ-aescine sodium respectively. The serum TNF-αwas determined before and 1 d, 2 d, 3 d, 5 d and 7 d after treatment. The patients were assessed with Glasgow Outcome Scale （GOS） 3 months after treat-ment. Results There was significant difference of serum TNF-αbetween treatment group and control group since 3 d after treatment （P〈0.05）. The score of GOS was better in the treatment group than in the control group 3 months after treatment （P〈0.05）. Conclusionβ-aes-cine sodium is effective on severe traumatic brain injury. Level of TNF-αmay be related with the outcome of patients with severe traumatic brain injury.