非溶栓脑梗死出血性转化危险因素分析

目的：探讨非溶栓脑梗死出血性转化（hemorrhagic transformation，HT）的危险因素。方法运用SPSS13.0软件对同期58例非溶栓脑梗死继发HT的病例和58例单纯脑梗死病例，对包括高血压病史、梗死面积、高胆固醇血症及心房颤动史等20项因素进行单因素分析和回顾性分析。结果两组患者Logistic回归分析显示，有统计学意义的有4项因素，根据OR值的大小依次排列为：脑梗死面积（OR=8.386，95%CI：3.237~28.326，P=0.003）、尿蛋白阳性（OR=5.622，95%CI：3.231~21.359，P=0.011）、心房颤动史（OR=4.923，95%CI：1.062~18.967，P=0.038）、血糖（OR=4.286，95%CI：1.027~16.481，P=0.042）。结论梗死面积、尿蛋白阳性、心房颤动史及高血糖是发生HT的危险因素。

Objective To investigate the non-hemorrhagic transformation of cerebral infarction thrombolysis（hemorrhagic transformation,HT） risk factors. Methods Using SPSS13. 0 software over the same period 58 cases of cerebral infarction secondary to non-thrombolysis cases and 58 cases of HT in simple cases,including a history of hypertension cerebral infarction, infarc t size,hypercholesterolemia,and history of atrial fibrillation and other 20 univariate analysis and retrospectively analyzed. Results Logistic regression analysis showed that two groups of patients were statistically significant in four factors,according to the size of the OR values in order of priority as follows：infarct size （OR=8.386,95%CI：3.237~28.326,P=0.003）,urinary protein positive （OR=5.622,95%CI：3.231~21.359,P=0.011）,history of atrial fibrillation （OR=4.923,95%CI：1.062~18.967, P=0.038）,blood glucose （OR=4.286,95%CI：1.027~16.481,P=0.042）. Conclusions Infarct size,urinary protein,atrial fibrillation and history of high blood sugar are risk factors of HT.