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EBV相关性IM患儿外周血白细胞和淋巴细胞亚群变化分析

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摘要 EB病毒（epstein-bait virus，EBV）属疱疹病毒科γ疱疹病毒亚科，为双链DNA病毒，人是唯一的自然宿主。有文献显示，全世界约有90%的人口曾感染过EBV［1，2］。儿童期EBV感染可直接引起传染性单核细胞增多症（infectious mononucleosis，IM），致人体细胞免疫紊乱。临床上可有发热、咽峡炎、淋巴结肿大、肝脾肿大、皮肤及黏膜皮疹等表现。作者自2012年3月至2013年5月采用全血细胞分析和流式细胞分析法，对本组EB病毒感染相关性IM患儿的外周血白细胞及淋巴细胞亚群进行分析，并与普通健康儿童比较，探讨其免疫细胞的变化特点，为EB病毒感染相关性IM患儿的诊断、治疗和预后判断提供实验室依据。报道如下。
作者 熊斌 孙杰 王家蔚 陈永琴
机构地区 浙江省湖州市中心医院儿科
出处 《浙江临床医学》 2014年第3期451-451,458,共2页 Zhejiang Clinical Medical Journal
关键词 EBV感染 淋巴细胞亚群 外周血白细胞 相关性 IM 患儿 传染性单核细胞增多症 EB病毒感染
分类号 R373 [医药卫生—病原生物学]
  • 相关文献

参考文献11

  • 1MacArthur GJ,Wilson AD,Birchall MA,et al Primary CD4^+ T-cell responses rovide both helper and cytotoxic functions during epstein- barr virus infection and trsnsformation of, fetal cord blood B cells.J Virol,2007,81 (9):4766~4775.
  • 2文飞球,张朝霞.EB病毒感染与淋巴增殖性疾病[J].实用儿科临床杂志,2008,23(3):163-165. 被引量：10
  • 3胡亚美 江载芳.诸福棠实用儿科学第七版[M].北京:人民卫生出版社,2002.698-704.
  • 4罗晓明,周馥英,周永列,王欣欣,邱莲女.儿童传染性单核细胞增多症B淋巴细胞及其活化状况的研究[J].中华儿科杂志,2004,42(9):701-704. 被引量：17
  • 5Karajannis MA,HurnmelM,Anagnostopoulos I,et al.Strictlymphotropism of Epstein Barr virus during acute infectious mononucleosis in nonimmunocompromised individuals.Blood,1997,89:2856~2862.
  • 6silins S L, Sherrittet M A, Silleri J M, el al. Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood Tcell repertoire perturbations despite high levels of systemic viral load.Blood. 2001, 98(13):3739~3742.
  • 7Ladell K,Domer M,Zauner L,et al.Immune activation suppresses in initiation of lyric Epstein-Barr virus infection. Cell M icrobiol, 2007, 9(8) :2055-2069.
  • 8Yajima M, Imadome KI, Nakagawa A, et al. A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses. J Infect Dis, 2008,198(5):673~682.
  • 9胡晨旻,宁伟伟,郭亚琼,孙梅.EB病毒感染儿童血淋巴细胞亚群变化的意义[J].实用儿科临床杂志,2010,25(10):733-735. 被引量：19
  • 10Scherrcnburg J,Piriou E P,,Nanlohy N M,et al.Detailed analysis of Epstein Barr vires-specific CD4+ and CD8+ T cell responses during infectious mononucleosis.Clin Exp Immunol,2008,153(2):231~239.

二级参考文献27

  • 1Karajannis MA, Hummel M, Anagnostopoulos I, et al. Strict lymphotropism of Epstein-Barr virus during acute infectious mononucleosis in nonimmunocompromised individuals. Blood, 1997,89: 2856-2862.
  • 2Niedobitek G, Agathanggelou A, Steven N, et al. Epstein-Barr virus (EBV) in infectious mononucleosis: detection of the virus in tonsillar B lymphocytes but not in desquamated oropharyngeal epithelial cells. Mol Pathol, 2000,53:37-42.
  • 3Tosato G, Taga K, Angiolillo AL, et al. Epstein-Barr virus as an agent of haematological disease. Baillieres Clin Haematol, 1995,8: 165-199.
  • 4Linde A, Andersson B, Svenson SB, et al. Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome. J Infect Dis, 1992, 165:994-1000.
  • 5Wilson AD, Redchenko I, Williams NA, et al. CD4 T cells inhibit growth of Epstein-Barr virus-transformed B cells through CD95-CD95 ligand-mediated apoptosis. Int Immunol, 1998,10:1149-1157.
  • 6Baumgarten E, Herbst H, Schmitt M, et al. Life-threatening infectious mononucleosis: is it correlated with virus-induced T cell proliferation? Clin Infect Dis, 1994,19: 152-156.
  • 7Stenfors LE, Bye HM, Raisanen S, et al. Bacterial penetration into tonsillar surface epithelium during infectious mononucleosis. J Laryngol Otol, 2000, 114: 848-852.
  • 8Arkkila E, Sipila J, Laurikainen E, et al. Peritonsillar abscess associated with infectious mononucleosis. ORL J Otorhinolaryngol Relat Spec, 1998,60: 159-163.
  • 9Shieh B, Schultz J, Guinness M, et al. Regulation of the human IgE receptor (Fc epsilonRII/CD23) by Epstein-Barr virus (EBV): Ku autoantigen binds specifically to an EBV-responsive enhancer of CD23. Int Immunol, 1997, 9: 1885-1895.
  • 10Lacy J, Roth G, Shieh B. Regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Localization of an intron EBV-responsive enhancer and characterization of its cognate GC-box binding factors. J Immunol, 1994,153: 5537-5548.

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浙江临床医学
2014年 第3期

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