6项血清肿瘤标志物的联合检测在肺癌诊断中的价值研究

The Combined Detection of 6 Tumor Markers for Diagnosis of Lung Cancer

目的：探讨6项肿瘤标志物水平与肺癌不同病理分型及分期的关系及在肺癌诊断中的价值.方法：应用蛋白芯片技术检测不同临床分期的147例患者及150例健康对照组血清中的6项肿瘤标志物水平,并进行统计学分析.结果：鳞癌、腺癌、SCLC的6项肿瘤标志物检测水平高于健康对照组,CEA在SCLC组高于鳞癌组、腺癌组;铁蛋白、CEA、CA19-9、CA125在鳞癌、腺癌、SCLC的阳性率均高于健康对照组,NSE在SCLC组阳性率高于健康对照组,CA242在鳞癌、腺癌组高于健康对照组;铁蛋白、CEA、CA19-9、CA125在肺癌Ⅰ~Ⅱ期、Ⅲ期、Ⅳ期的阳性率均高于健康对照组;6项肿瘤标记物联合检测的敏感度（78.91%）明显高于单项检测的敏感度（分别为38.10%、57.82%、0.01%、61.90%、48.30%和14.97%）.结论：6项肿瘤标志物的联合检测可明显提高肺癌诊断的敏感性,肿瘤标志物的联合检测对肺癌的诊断具有重要价值.

Objective：To study the expression of 6 tumor markers in different pathological typies of lung cancer and explore the feasibility of its clinical application.Methods：The serum levels of 6 tumor markers were detected by protein biochip technology in 147 cases of lung cancer and 150 cases of normal control.Results：The levels of serum Ferritin,CEA,CA19-9,CA125 in all kinds of lung cancer patients were significantly higher than those in normal control.The expression level of NSE in SCLC and CA242 in squamous cell carcinoma,adenocarcinoma were significantly higher than those in normal control.The positive rates of Ferritin,CEA,CA19-9,CA125 in patients of different stages were higher than that in normal control.The sensitivity of combination detection（78.91%） were significantly higher than that of single item（38.10%,57.82%,0.01%,61.90%,48.30% and 14.97%, respectively）.Conclusion：The combined detection of 6 tumor markers could increase the diagnostic sensitivity of lung cancer,it was proved to be useful for the diagnosis of lung cancer.