醒脑静对急性酒精中毒患者炎性因子含量的影响

Effect of Xingnaojing injection on piasma inflammatory factor in patients with acute ethanol intoxication

目的 探讨急性酒精中毒患者血浆炎性因子含量的变化及醒脑静对其影响.方法 选取甘肃省兰州市第一人民医院严重急性酒精中毒患者50例,采用随机数字表法分为常规治疗组（对照组）和醒脑静＋常规治疗组（观察组）,各25例.分别检测2组患者治疗前后内皮素1、一氧化氮、肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）含量的变化,并与20名体检者健康（正常组）进行对比分析.结果 对照组和观察组治疗前后的内皮素1、一氧化氮、TNF-α和IL-6[对照组：治疗前（77±7）ng/L、（34±10）μmol/L、（2.6±0.1）ng/L、（31.3±3.2）ng/L,治疗后（68±6）ng/L、（48±10）μmol/L、（2.2±0.2）ng/L、（26.3±3.1）ng/L;观察组：治疗前（78±7）ng/L、（35±11）μmol/L、（2.6±0.2）ng/ml、（32.4±3.1）ng/L,治疗后（62±7）ng/L、（57±9）μmol/L、（2.0±0.3）ng/ml、（22.6±3.2）ng/L]与正常组[（55±9）ng/L、（57±14）μmol/L、（2.0±0.4）ng/ml、（16.6±2.8）ng/L]相比,差异均有统计学意义（均P〈0.01）.观察组、对照组治疗后血浆内皮素1、一氧化氮、TNF-α、IL-6与治疗前比较,差异均有统计学意义（均P〈0.05）.观察组治疗后血浆内皮素1、TNF-α及IL-6显著低于对照组（P〈0.01）,一氧化氮明显高于对照组（P〈0.01）.结论 急性酒精中毒患者血中内皮素1、TNF-α和IL-6明显升高,一氧化氮水平降低,醒脑静治疗后可降低内皮素1、TNF-α和IL-6,提高一氧化氮水平,具有改善急性酒精中毒病理损害的作用.

Objective To observe the effect of Xingnaojing injection on plasma inflammatory factor in patients with acute ethanol intoxication. Methods Fifty severe acute ethanol intoxication patients were randomly divided into two groups： control group was treated with conventional therapy; observation group had the conventional treatment and Xingnaojing injection. Endothelin-1（ET-1）, nitric oxide（NO）, tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6） in the two groups were detected before and after treatment and compared with henalthy person（normal group）. Results ET-1, NO, TNF-α and IL-6 of the control group and observation group before and after treatment were：[control group before treatment： （77±7）ng/L, （34±10）μmol/L, （2.6±0.1）ng/ml, （31.3±3.2）ng/L; control group after treatment： （68±6）ng/L, （48±10）μmol/L, （2.2±0.2）ng/ml, （26.3±3.1）ng/L; observation group before treatment： （78±7）ng/L, （35±11）μmol/L, （2.6±0.2）ng/ml,（32.4±3.1）ng/L; observation group after treatment： （62±7）ng/L, （57±9）μmol/L,（2.0±0.3）ng/ml, （22.6±3.2）ng/L] compared with control group [（55±9）ng/L, （57±14）μmol/L, （2.0±0.4）ng/ml, （16.6±2.8）ng/L]; there were all statistical differences （P〈0.01）. There were also statistical differences on ET-1, NO, TNF-α and IL-6 between the control group and observation group after treatment（P〈0.05）. ET-1, TNF-α and IL-6 of the observation group after treatment were lower than those of control group （P〈0.01）.NO was higher than that of control group （P〈0.01）. Conclusions The plasma NO decreases and ET-1, TNF-α, IL-6 increase in acute ethanol intoxication patients. Xingnaojing injection can significantly raise the level of NO and reduce ET-1, TNF-α and IL-6, which can improve the pathological damage of acute alcohol poisoning.