脑梗死与糖代谢异常相关性研究

The Correlation Study of Cerebral Infarction and Abnormal Glucose Metabolism

目的:观察不同损害程度脑梗死患者的血糖水平,分析其糖代谢异常情况,探讨脑梗死与糖代谢异常的关系,为脑梗死的预防、诊断、治疗提供依据。方法:选取2010年1月-2013年8月入住本院脑病科的108例急性脑梗死患者,根据梗死范围将其分为轻度组41例、中度组40例、重度组27例,通过检测空腹血糖(FPG)、餐后2 h血糖(PG)、糖化血红蛋白(HbA1c),观察患者的糖代谢情况。结果:糖调节受损、糖尿病与正常血糖患者比较,中度及重度组脑梗死比率明显升高;糖尿病患者脑梗死中度组、重度组比率较糖调节受损患者明显升高;脑梗死中度组、重度组的HbA1c、FPG、2 h PG水平均明显高于脑梗死轻度组,重度组的HbA1c、FPG、2 h PG水平明显高于中度组,差异均有统计学意义(P<0.05)。结论:糖代谢异常与脑梗死的发生及损害程度明显相关,良好的血糖控制有利于降低脑梗死的发生率,监测血糖并控制正常范围内可改善预后。

Objective：To observe blood glucose levels of cerebral infarction patients with different damage degrees, and to analyze the situation of abnormal glucose metabolism of patients with cerebral infarction,and to explore the relationship between cerebral infarction and glucose metabolism in order to provide the reference for prevention,diagnosis and treatment of cerebral infarction.Method：108 cases of acute cerebral infarction were selected from January 2010 to August 2013 admitted to our hospital department of encephalopathy,according to the scope of infarction cerebral infarction the damage degrees, they were divided into the mild degree for 41 cases,the moderate degree for 40 cases and the severe degree for 27 cases,and the situation of glucose metabolism in patients were observed by detecting fasting plasma glucose（FPG）,blood sugar 2 hours after meal（PG）and glycosylated hemoglobin（HbA1c）.Result：Sugar regulation damaged,diabetes mellitus,compared with normal blood glucose in cerebral infarction patients with moderate and severe group were significantly increased;Cerebral infarction in patients with diabetes moderate group and severe group were significantly increased in patients with impaired glucose regulation;HbA1c,FPG,2 h PG levels of cerebral infarction group and moderate severe group were significantly higher than those of mild cerebral infarction group,HbA1c,FPG,2 h PG levels of severe group were significantly higher than that of the moderate group,the differences were statistically significant（P〈0.05）.Conclusion：The abnormal glucose metabolism is obviously correlated with the occurrence of cerebral infarction and damage degree,and good blood glucose control is beneficial to reduce the incidence of cerebral infarction,in the same time monitoring and controlling blood sugar in a normal range can improve the prognosis.