维生素D受体的BsmI基因多态性与结核病的风险关系Meta分析

Meta- analysis of the association of vitamin D receptor Bsml gene polymorphism with risk of tuberculosis： a meta - analysis of 15 studies

目的应用荟萃分析探讨维生素D受体（VDR）的BsmI基因多态性与结核易感性的关系。方法在PubMed、EMBASE和中国期刊全文数据库（CM（I）对1998年1月1日一2013年3月19日数据进行系统的文献检索，对检索得到的15项研究进行全面荟萃分析。评估VDR的BsmI基因多态性与结核发病风险之间的关联强度，并进行人群种族亚组分析。结果Meta分析结果发现VDR的BsmI基因多态性合并OR（95%CI）分别为等位基因模型（b vs B：OR=0．78，95％CI=0．67，0．89），纯合子模型（bb vs BB：OR=0．61，95％CI=0．43，0．87），显性遗传模型（bb＋Bb伪BB：OR=0．77，95％CI=0．61，0．97），隐形遗传模型（bb vs Bb＋BB：OR=0．70，95％CI=0．56，0．88）。亚组分析结果显示VDR的BsmI基因多态性与亚洲人群的结核发病风险存在显著关联。结论荟萃分析表明，VDR的BsmI基因多态性为结核发病的危险因素，尤其在亚洲人群中风险更加显著。

Objective To study the association between vitamin D receptor gene（VDR）BsmI polymorphism and tubercu- losis（TB）risk by metaanalysis. Methods A systematic literature searching was performed on PubMed,EMBASE and Chinese National Knowledge Infrastructure（CNKI）up to March 19,2013.We performed a comprehensive metaanalysis of 15 publications. We assessed the association between VDR BsmI gene polymorphism and TB risk and performed sub - group analyses by ethnicity, sample size and Hardy Weinberg equilibrium（HWE）. Results We found a statistically significant correlation between VDR BsmI gene polymorphism and decreased TB risk in four comparison models：allele model（b ta B： OR = 0.78,95% CI = 0.67,0.89）, homozygote model（bb vs BB： OR = 0.61,95% CI = 0.43,0.87） ,recessive model（bb vs Bb ＋ BB： OR = 0.70,95% CI = 0.56,0.88）and dominant model（bb ＋ Bb vs BB： OR = 0.77,95% CI = 0.61,0.97）, especially in studies based on Asian population. Conclusion This meta- analysis suggests that VDR BsmI gene polymorphism is associated with a significant decrezsed TB risk,especially in Asians.