乳腺癌多线与一线内科解救治疗病例对照研究

A Case-control Study between Multi-line and First-line Internal Medicine of Rescue Therapy for Breast Cancer

目的探讨乳腺癌治疗方案的全程合理有效实施方法。方法收集沈阳军区总医院2008年1月—2013年5月收治的乳腺癌中接受四线及四线以上内科解救治疗56例(多线组),同时随机抽取同时期接受一线解救治疗的56例为一线组,回顾性分析两组的临床资料。结果多线组与一线组比较,≥60岁、单纯化疗、化疗联合靶向治疗、淋巴结转移数、病理分级程度方面,差异均有统计学意义(P<0.05)。多线组在疾病自然进展、随意更换方案、擅自减少剂量方面,明显高于一线组(P<0.05)。结论对一般状况较好、预期生存较长,能从多种治疗方案中获益的乳腺癌患者,应该尽量高效、合理、有序的实施数量有限的治疗方案。

Objective To explore the reasonable and effective methods in treatment of breast cancer in the whole course of the disease. Methods During January 2008 and May 2013, 56 patients with breast cancer, who received four- line or more internal medicine of rescue therapy, were chosen as group A, and 56 random patients with breast cancer, who received first-line internal medicine of rescue therapy, were chosen as group B. Clinical data in the two groups was retro- spectively analyzed. Results The differences in patients were or over 60 years old, only chemotherapy, chemotherapy combined with targeted therapy, the number of lymph node metastasis and pathological grades in the two groups were sta- tistically significant （P 〈 0. 05）. The degree of natural progression of the disease, freewill change of therapy methods and unauthorized dose reduction in group A were significantly higher than those in group B （P 〈 0.05）. Conclusion Limit- ed number of treatment methods should be implemented efficiently, rationally and orderly in breast cancer patients, who have good condition in general, longer life expectance and may benefit from multiple therapic methods.