摘要
目的 观察帕洛诺司琼防治乳腺癌化疗相关性恶心呕吐的疗效及安全性.方法 选择2010年1月-2013年6月沈阳军区总医院收治的乳腺癌77例,其中帕洛诺司琼组(A组)38例和托烷司琼组(B组)39例.两组患者均采用含表柔比星方案化疗,分别观察两组化疗后0~5 d内出现恶心、呕吐及食欲不振等消化道反应和便秘、头晕等不良反应.结果化疗后0~24 h两组恶心、呕吐及食欲不振控制率差异均无统计学意义(P>0.05),化疗后2~5 d A组对恶心、呕吐控制率明显优于B组(P<0.05),食欲不振控制率无差异(P>0.05).两组不良反应较轻,无明显差异(P>0.05).结论 在乳腺癌化疗中,帕洛诺司琼防治表柔比星引起迟发性恶心呕吐疗效显著,安全性高.
Objective To observe the curative effect and safety of Palonosetron in prevention of chemotherapy- related nausea and vomiting in patients with breast cancer. Methods A total of 77 inpatients with breast cancer during January 2010 and June 2013 were randomly divided into Palonosetron group (group A, n = 38) and Tropisetron group (group B, n = 39). All the patients underwent Epirubicin-containing chemotherapy. The episodes of loss of appetite, nausea and vomiting, and adverse effects such as constipation and dizziness in the two groups within 0-5 d after the chem- otherapy were observed. Results The control rates for loss of appetite, nausea and vomiting in the two groups within 0 - 24 h after chemotherapy showed no statistical differences ( P 〉 0.05 ). The control rates for nausea and vomiting in group A within 2 - 5 d after chemotherapy were significantly better than those in group B (P 〈 0. 05), but the difference in control rate for loss of appetite was not statistically significant (P 〉 0.05). No serious adverse effect was observed in the two groups (P 〉 O. 05). Conclusion Palonosetron has significant efficacy and high safety in prevention of chemo- therapy-related tardive nausea and vomiting in Epirubicin-containing chemotherapy for breast cancer.
出处
《解放军医药杂志》
CAS
2014年第3期27-30,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
科技部十二五重大新药创制平台子课题(2012ZX09303016-002)
2012年辽宁省科技攻关计划课题(2012225019)