摘要
随着白三烯受体拮抗剂孟鲁司特在儿童支气管哮喘治疗中的应用,其药物疗效的个体差异及相关影响因素备受关注.目前此方面的研究虽取得了一定进展,但尚处于开展阶段,已有的研究结果仍存在颇多争议.该文主要对影响孟鲁司特疗效的相关因素,包括患儿个体特征、体重指数、吸烟环境暴露及遗传变异等进行综述,旨在对孟鲁司特用药的选择提供相关参考因素,促进药物治疗个体化,提高药物疗效,达到哮喘理想控制.
As the application of leukotriene receptor antagonists （LTRA） is widely used among children with asthma,the heterogeneity of response to montelukast and its related factors are attracting more and more attention.At present,the research has made some progresses,but it is still in the stage of development and cannot reach a consensus.The related factors,including individual characteristics,body mass index,smoking exposure,genetic factors are described in this review,to improve the rationality of drug selection in order to reduce side effects 、improving therapeutic efficacy and achieve good asthma control.
出处
《国际儿科学杂志》
2014年第2期124-127,共4页
International Journal of Pediatrics
关键词
白三烯受体拮抗剂
哮喘
治疗效果
儿童
Leukotriene receptor antagonist
Asthma
Treatment response
Children
