外周血CD34^+细胞与脑外伤患者预后关系的临床研究

Relationship between peripheral blood CD34^+ cells and the prognosis of patients with brain trauma

目的观察外周血CD34+细胞与脑外伤患者预后关系。方法随访脑外伤患者6个月,用格拉斯哥昏迷评分(GCS),分为预后良好组和预后不良组。单因素分析比较2组入院时外周血CD34+细胞、格拉斯哥昏迷评分(GCS)及蛛网膜下腔出血、瞳孔散大、中线偏移、环池消失比例的差别。用Logistic多元回归分析外周血CD34+细胞与脑外伤患者预后的关系。结果预后良好组GCS评分显著高于预后不良组(P<0.01);预后良好组蛛网膜下腔出血、瞳孔散大、中线偏移、环池消失比例及外周性CD34+细胞数量显著低于预后不良组(均P<0.01)。GCS和外周血CD34+细胞均为脑外伤患者预后的影响因素。结论脑外伤患者外周血CD34+细胞水平升高,且其水平越高,患者预后越差。

Objective To explore the relationship between peripheral blood CD34＋ cells and the prognosis of patients with brain trauma. Methods One hundred sixty patients with brain trauma were divided into the good prognosis group and the poor prognosis group according to the Glasgow coma score （GCS） after 6 months follow up. Firstly, the single factor analysis was used to compare the peripheral blood CD34＋ cells count, GCS and the percentages of subarachnoid hemorrhage, corectasis, midline shift and cisterna ambiens disappear between the two groups.The Logistic multiple regression analysis was used to explore the effect of peripheral blood CD34＋ cells count on the prognosis of patients with brain trauma. Results The GCS in the good prognosis group was significantly higher than that in the poor prognosis group （P〈0.01）.The peripheral blood CD34＋ cells count and the percentages of subarachnoid hemorrhage, corectasis, midline shift and cisterna ambiens disappear in the good prognosis group were significantly lower than that in the poor prognosis group （P〈0.01）. The Logistic multiple regression analysis showed that the GCS and the peripheral blood CD34＋cells count were all the influencing factors of prognosis in patients with brain trauma. Conclusion The peripheral blood CD34＋ cells count increased in the patients with brain trauma, which was associated with the prognosis of them.