三维适形放疗联合培美曲塞治疗非鳞癌局部晚期肺癌的近期疗效及毒性反应

The Efficacy and Toxicity of Three-dimensional Conformal Radiotherapy Combined with Pemetrexed in Treatment of Locally Advanced Non-squamous Lung Cancer

目的:观察三维适形放疗联合培美曲塞治疗非鳞癌局部晚期肺癌的近期疗效及毒性反应。方法:将2009年10月至2012年6月期间我院收治的非鳞癌局部晚期肺癌患者98例,将其随机分为观察组49例和对照组49例,观察组患者给予三维适形放疗联合培美曲塞进行治疗,对照组患者仅给予三维适形放疗,观察两组患者治疗的临床疗效及两组患者治疗后毒性反应的发生率。结果:两组患者经治疗后均取得一定的临床效果,观察组患者的有效率为63.3%明显高于对照组的32.7%,差异具有统计学意义(P<0.05);观察组患者毒性反应的发生率与对照组相比无显著差异(P>0.05)。结论:三维适形放疗治疗非鳞癌局部晚期肺癌时应用培美曲塞能够显著提高患者的临床疗效,且用药后的毒性反应发生率没有增加,值得在临床普遍推广与应用。

Objective：To observe the efficacy and toxicity of the three-dimensional conformal radiother-apy combined with pemetrexed in the treatment of locally advanced non-squamous lung cancer .Method：98 patients with non-squamous locally advanced lung cancer were selected from October 2009 to June 2012 .The patients were randomly divided into observation group and control group , and each group with 49 cases.The observation group was treated with three-dimensional conformal radiotherapy combined with pemetrexed , while the control group was only treated with three-dimensional conformal radiotherapy .The clinical efficacy and the incidence of toxicity of the two groups were observed after treatment .Result： After treatment , the patients of the two groups had certain clinical affect .The effective rate of observation group was 63.3%higher than 32.7%of the control group, the difference was statistically significant （P＆lt;0.05）;the incidence of tox-icity had no difference between the two groups , the difference was not statistically significant （P＆gt;0.05）. Conclusion：The three-dimensional conformal radiation therapy for locally advanced non -squamous lung cancer combined with pemetrexed can significantly improve the clinical efficacy , and the incidence of toxicity did not increase after treatment , it is worth to be general promoted and applied in clinical .