静脉预注小剂量氯胺酮对丙泊酚注射痛的影响

The effect of pre-injecting small dose ketamine on propofol injection pain

目的观察小剂量氯胺酮对丙泊酚注射痛的影响。方法择期行全麻手术患者180例,随机均分为六组:静注生理盐水(S组)、利多卡因0.5mg/kg(L组)及氯胺酮25μg/kg(K25组)、50μg/kg(K50组)、75μg/kg(K75组)、100μg/kg(K100组)后静注丙泊酚2mg/kg。注射过程每隔5秒对患者行疼痛语言描述评分(VRS评分)并记录苏醒时间。结果六组患者性别构成、年龄、体重、苏醒时间等差异无统计学意义。S、L、K25、K50、K75、K100组的注射痛发生率分别为26例(86.7%)、14例(46.7%)、13例(43.3%)、12例(40.0%)、12例(40.0%)及11例(36.7%);与S组比较,L、K25、K50、K75及K100组患者注射发生痛明显降低(P<0.05);与L组比较,K25、K50、K75及K100组患者注射痛发生率明显降低(P<0.01)。结论小剂量氯胺酮可有效的预防丙泊酚注射痛。

Objective To observe the effect of pre-injecting small doses ketamine on propofol injection pain.Methods One hundred and eighty patients undergoing surgeries under general anesthesia randomly and equally divided into six groups,propofol 2 mg/kg with saline 5 ml （group S）,with lidocaine 0.5 mg/kg （group L）,and with ketarnine 25 μg/kg （group K25）,50 μg/kg （group K50）,75 μg/kg （group K75）,100 μg/kg （group K100） were administrated intravenously,respectively.The pain of patients were evaluated by verbl rting scle （VRS） at 5 seconds interval during injection and the recovery time were also recorded in all the groups.Results The incidences of injection pain in groups S,L,K25,K75 and K100 were 26 （86.7％）,14 （46.7％）,13 （43.3％）,12 （40.0％）,12（40.0％）,and 11（36.7％）,respectively.The VRS significantly decreased in the other groups compared with group S （P＜0.05） ; the VRS in groups K25,K50,K75 and K100VRS were lower than that in group L （P＜0.01）.Conclusion Small doses of ketamine could effectively prevent the propofol injection pain.