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组蛋白去乙酰化酶在认知功能障碍中的作用 被引量：1

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摘要 表观遗传学是指在不改变DNA序列的情况下发生的可遗传变异的学科,主要包括DNA甲基化,组蛋白乙酰化、甲基化、磷酸化、泛素化等,其中组蛋白乙酰化是表观遗传学最为常见类型之一.组蛋白乙酰化主要发生组蛋白H3和H4 N-端尾部的赖氨酸残基上,受组蛋白乙酰转移酶（histone acetyltransferases,HATs）和组蛋白去乙酰化酶（histone deacetylases,HDACs）的调节,其水平高低与基因的转录激活和抑制密切相关.
作者 贾敏 纪木火 杨建军 徐建国
机构地区 南京大学医学院临床学院南京军区南京总医院麻醉科
出处 《临床麻醉学杂志》 CAS CSCD 北大核心 2014年第3期306-308,共3页 Journal of Clinical Anesthesiology
基金 国家自然科学基金(81271216 81300946)
关键词 组蛋白去乙酰化酶 认知功能障碍 组蛋白乙酰化 组蛋白乙酰转移酶 DNA甲基化 基因的转录激活 表观遗传学 DNA序列
分类号 R749.1 [医药卫生—神经病学与精神病学]
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同被引文献10

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临床麻醉学杂志
2014年 第3期

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