非高密度脂蛋白胆固醇与冠状动脉支架内再狭窄及病变加重的关系

Relations between non-high-density lipoprotein cholesterol and coronary in-stent restenosis, dete-rioration of atherosclerotic plaques

目的探讨非高密度脂蛋白胆固醇与冠状动脉支架内再狭窄及病变加重的关系。方法总结郑州大学第一附属医院成功行经皮冠状动脉介入治疗术后12个月回院复查冠状动脉造影的226例患者的临床资料，并分为进展组（冠状动脉支架内再狭窄及冠状动脉粥样硬化病变加重）和稳定组（无支架内再狭窄及无其他冠状动脉病变加重者），对两组介入前及回院复查时的血脂指标分别进行回顾性研究分析。结果进展组54例（冠状动脉支架内再狭窄及冠状动脉粥样硬化病变加重），稳定组172例（无支架内再狭窄及无其他冠状动脉病变加重），对复查时两组的总胆固醇、低密度脂蛋白胆固醇及非高密度脂蛋白胆固醇进行比较及统计学分析，三者差异均有统计学意义。结论总胆固醇、低密度脂蛋白胆固醇及非高密度脂蛋白胆固醇是冠状动脉支架内再狭窄及未行介入治疗的其他冠状动脉管腔狭窄加重的重要危险因素，后者的预测价值优于前两者。

Objective To study the relationships between non-high-density lipoprotein cholester- ol and coronary in-stent restenosis, deterioration of atherosclerotic plaques. Methods The clinical data of 226 patients with coronary heart disease, who were treated by percutaneous coronary intervention（PCI）, were sunmarized. After 12 months, the patients were reviewed by the coronary angiography, and they were divided into twogroups ： lesions progress group （ coronary in-stent restenosis and deterioration of atherosclerotic plaques）, no lesions progress group （ no coronary in-stent restenosis or deterioration of atheroselerotic plaques）. Re- suits Among all the 226 patients, 54 cases were diagnosed as coronary in-stent restenosis and deteriora- tion of atherosclerotic plaques, 172 eases without lesions progress. There were significant differences in total cholesterol （ TC ）, low-density lipoprotein cholesterol （ LDL-C ）, and non-high-density lipoprotein cholesterol （non-HDL-C） between the two groups. Conclusions TC, LDL-C, non-HDL-C may be im- portant risk factors for the coronary stent restenosis after PCI, but the predictive value of non-HDL-C is superior to TC or LDL-C.