性激素水平及ER、PR表达与乳腺纤维腺瘤的关系

Relationship between sex hormone levels, ER, PR expression and breast fibroadenoma

目的研究性激素水平及雌激素受体（ER）、孕激素受体（PR）表达在乳腺纤维腺瘤中的变化及意义。方法将研究对象分为纤维腺瘤组和正常组。采用化学发光法测定各组黄体期血清雌激素（E2）、孕酮（P）、泌乳素（PRL）水平，同时应用免疫组化法检测纤维腺瘤组中ER、PR的表达。结果纤维腺瘤组E2水平明显高于正常组，差异有统计学意义（P〈0．05），两组P、PRL水平比较差异无统计学意义（P〉0．05）。纤维腺瘤组中ER的阳性率为94．7％，PR的阳性率为69．3％，ER阳性强度差异有统计学意义（P〈0．05）。结论E2升高及ER高表达是乳腺纤维腺瘤发生的主要原因，与乳腺增生病原因相似。据此，临床上可采取措施对其进行积极治疗。

Objective To study the changes of sex hormone level, estrogen receptor （ER） and progesterone receptor （PR） expression levels and their significance in fibroadenoma of,breast. Methods The study objects were divided into fibroadenoma group and normal group. Chemiluminescence method was used to detect the luteal phase serum estrogen （E2）, progesterone （P）, prolactin （PRL） levels, and immunohistochemistry was used to detect ER, PR levels in fibroadenoma group. Results The level of E2 in fibroadenoma group was significantly higher than that in normal group, there was significant differ- ence between the two groups （P 〈 0.05 ）. There were no significant differences in P and PRL levels be- tween the two groups （P 〉 0.05 ）. The positive rate ER in fibroadenoma group was 94.7%, the positive rate of PR was 69.3%, and the differences were statistically significant for ER positive intensity between the two groups （P 〈 0.05 ）. Conclusions The elevated levels of E2 and high expression levels of ER are the main reasons of breast fibroadenoma, which are similar to the causes of hyperplasia of mammry gland. So, active treatment should be given in clinics.