B型钠尿肽基础与临床研究进展

Basic and clinical research progress of B type natriuretic peptide

目的探讨血浆B型钠尿肽（BNP）水平与心力衰竭的诊断、严重程度和预后的关系。方法选择在滨州市人民医院老年科住院的心力衰竭患者300例（治疗组），测定其入院时血浆BNP水平，并与同期健康体检者（对照组）作对比，并随访其出院后2年内因心力衰竭再住院和死亡的情况。结果治疗组BNP水平均高于健康对照组（P〈0．01）；BNP水平与心功能分级关系密切，治疗组BNP水平随着心功能的加重而升高，呈明显正相关（r=0．79，P〈0．01），而左室射血分数（LYEF）随着心功能的加重而降低，呈明显负相关（r=-0．73，P〈0．01），BNP水平高的患者2年内再住院率和病死率均高。结论血浆BNP水平可以用于心力衰竭的诊断、严重程度判断和预后评估。

Objective To investigate the relationship between the levels of plasma B type natriuretic peptide （BNP） and the diagnosis, severity and prognosis in elderly inpatients with heart failure. Methods Three hundred elderly patients with heart failure were selected, the plasma BNP levels were measured on admission, and were compared with healthy controls in same period, and the heart failure readmission and death situation during 2 years after discharge was fol- lowed-up. Results The BNP level in treatment group was higher than that in healthy controls （ P 〈 O. O1 ） ; the level of BNP was closely related to cardiac functional grading, in treatment group, the level of BNP increased with the deterioration of the cardiac function, there was a positive correlation （r = 0. 79, P 〈 0.01 ） ; and LVEF decreased with deterioration of the cardiac function, there was a negative correlation （ r = - 0. 73, P 〈 0.01 ）. Patients with high levels of BNP had higher rehospitalization rate and mortality with in 2 years. Conclusions The level of plasma BNP can be used for the diagnosis, severity ossessment and prognosis evaluation of heart failure.