血清TSGF、SCC联合检测在宫颈癌诊断中的应用价值

Clinical value of serum tumor markers SCC and TSGF in cervix carcinoma diagnose

目的:探讨肿瘤标志物鳞状细胞癌抗原(squamous cell carcinoma associated antigen,SCC)和肿瘤特异性生长因子(tumor specific growth factor,TSGF)在宫颈癌诊断中的应用价值。方法:收集40例健康体检者、56例宫颈上皮内瘤样病变(cervical intraepithelial neoplasia,CIN)患者和101例宫颈癌患者,采用化学发光法和生化比色法分别检测各组SCC和TSGF的含量,然后进行比较分析。结果:宫颈癌组血清SCC、TSGF的含量分别为(6.95±1.23)ng/mL和(81.0±16.3)U/mL,明显高于CIN组和对照组(P<0.05),两者联合检测的敏感性和准确性分别为91.1%和87.4%,均明显高于单项检测(P<0.05)。结论:SCC和TSGF对宫颈癌的辅助诊断具有重要的临床意义,两者联合检测明显提高宫颈癌患者诊断的敏感性及准确性。

Objective To explore the clinical value of squamous cell carcinoma associated antigen （SCC） and tumor specific growth factor （TSGF） in cervical carcinoma, diagnose. Methods The serum samples of SCC and TSGF were collected from 40 health volunteers, 56 cervical intraepithelial neoplasia （CIN） patients and 101 squamous cell cervical cancer patients. SCC and TSGF amount were measured by MEIA and biochemistry olorimetry method respectively, and were compared. Results The mean level of serum SCC and TSGF in the cervical cancer group was （6.95 ±1.23） ng/mL and （81.0 ±16.3）U/mL respectively, significantly higher than that in the CIN group and control group. The sensitivity and accuracy of combining SCC with TSGF in diagnosing cervical carcinoma were 91.1% and 87.4% respectively, both higher than allying SCC or TSGF alone. Conclusions SCC and TSGF levels are helpful in the diagnosis of cervix carcinoma. The combined determination can improve the sensitivity and accuracy of cervical carcinoma diagnose.