小儿EB病毒感染性咽炎与肠系膜淋巴结炎的相关性

Association of EB virus-induced pharyngitis with mesenteric lymphadenitis in children

目的:分析小儿EB病毒感染性咽炎伴有消化道症状与肠系膜淋巴结炎的临床关系,探讨EBVVCA-IgM检测和彩色多普勒超声检查对小儿EBV感染性肠系膜淋巴结炎的诊断价值。方法:对356例咽炎伴有消化道症状患儿进行前瞻性调查分析。经实验室用血清ELISA法检测EBV-VCA-IgM阳性患儿162例为观察组,阴性患儿194例为对照组。两组彩色多普勒超声检查肠系膜淋巴结大小、数目及血流情况,进行统计、对比分析。结果:观察组肠系膜淋巴结炎43例,对照组肠系膜淋巴结炎11例,两组比较,差异有统计学意义(P<0.01)。结论:小儿EB病毒感染咽炎伴有消化道症状患儿可合并肠系膜淋巴结炎,血清ELISA法检测EBV-VCA-IgM和彩色多普勒超声检查对小儿EBV感染性肠系膜淋巴结炎有一定的临床诊断价值。

Objective To analyze the clinical con＇elation between EB virus-induced pharyngitis with gastrointestinal symptoms and mesenteric lymphadenitis in children, and to explore the value of EBV-VCA-IgM deetection and color Doppler ultrasound in the diagnosis of EB virus-induced mesenteric lymphadenitis. Methods 356 children with pharyngitis complicated by gastrointestinal symptoms were prospectively analyzed. 162 patients who had a postive result of EBV-VCA-IgM detection by ELISA were assigned to a study group, while another 194 patients who had a negative result were assigned to a control group. The size, number and blood flow of mesenterie lymph nodes were determined by color Doppler ultrasound in both groups. The data were counted, compared and analyzed. Results 43 children had mesenteric lymphadenitis in the study group, so had 11 in the control group. There was a significant difference between the two groups （P 〈 0.01 ）. Conclusions Children with pharyngitis complicated by gastrointestinal symptoms may suffer from mesenteric lymphadenitis. ELISA for EBV- VCA-IgM detection and color Doppler ultrasound have certain clinical value in the diagnosis of mesenteric lymphadenitis indcued by EB virus infection.