期刊文献+

基于CT影像的颈动脉分叉血流动力学特性分析 被引量:5

Hemodynamic Characteristics Analysis of Carotid Artery Bifurcation Based on CT Images
下载PDF
导出
摘要 利用实际病人的CT影像数据构建颈动脉分叉血管几何模型,利用ANSYS有限元软件计算血流速度和压力分布,对颈动脉血流动力学的特征进行分析,如颈动脉剪切应力在一个心动周期里不同时刻的变化情况,颈动脉窦部的血流速度场随时间变化情况,涡流形成的特点;然后分析颈总动脉、颈内动脉和颈外动脉的血流阻力变化情况.数值仿真结果表明,在心动周期的不同时刻,颈动脉窦部的剪切力几乎是最小的.在颈动脉窦部下方附近,涡流易于形成.在收缩期的开始阶段,动脉阻力有一个很大的高峰.这些特点会对研究颈动脉血管疾病有一定的启发. The geometric model of a carotid artery bifurcation was constructed from the CT images of a real patient. Using this model, the velocity and pressure distribution of the carotid arteries were simulated by a finite element software ANSYS. Further analysis was done on the hemodynamic characteristics of the carotid artery bifurcation, such as the wall shear stress distribution at different time points, the blood velocity field at different time points, and the characteristics of turbulence. Finally the blood resistance of carotid arteries was analyzed. The results turned out that the wall shear stress is almost the lowest at the sinus, the turbulence occurs nearby the sinus. There is a high pulse for blood resistance at the beginning of systole period. These findings could be useful for relevant research of cardiovascular diseases.
出处 《东北大学学报(自然科学版)》 EI CAS CSCD 北大核心 2014年第3期356-360,共5页 Journal of Northeastern University(Natural Science)
基金 国家自然科学基金资助项目(61372014) 辽宁省自然科学基金资助项目(201202071)
关键词 颈动脉 计算流体力学 血流阻力 CT影像 有限元法 carotid artery computational fluid dynamics blood resistance CT image finiteelement method
  • 相关文献

参考文献13

  • 1Kojima M, Tercero C, Ikeda S, et al. Numerical simulation for blood flow in internal carotid artery for integration with photoelastic stress analysis I C ]//IEEE Engineering in Medicine and Biology Society. Buenos Aires, 2010 : 384 - 389.
  • 2Nguyena K T, Clarka C D, Chancellora T J, et al. Carotid geometry effects on blood flow and on risk for vascular disease[ J]. Journal of Biomechanics,2008,41 ( 1 ) : 11 - 19.
  • 3Strond J S, Berger S A, Saloner D. Influence of stenosis morphology on flow through severely stenotic vessels: implications for plaque rupture [ J ]. Journal of Biomechanical Engineering,2000,33 (4) :443 - 455.
  • 4Tang D, Yang C, Kobayashi S, et al. Effect of a lipid pool on stress/strain distributions in stenotic arteries: 3-D fluid- structure interactions ( FSI ) models [ J ]. Journal of Biomechanical Engineering ,2004,126 ( 3 ) :363 - 370.
  • 5Sun Z, Mwipatayi B, Chaichana T, et al. Hemodynamic effect of calcifed plaque on blood flow in carotid artery disease : a preliminary study[ C]//The 3rd International Conference on Bioinformafics and Biomedical Engineering. Beijing, 2009: 1-4.
  • 6Stouffer G A. Cardiovascular hemodynamics for the clinician M ]. Massachusetts: Blackwell Publishing,2008.
  • 7刘有军,乔爱科,主海文,高松.颈动脉分支的血流动力学数值模拟[J].计算力学学报,2004,21(4):475-480. 被引量:17
  • 8Arts T, Delhaas T, Bovendeerd P, et al. The CircAdapt model adaptation to mechanical load determines shape and properties of heart and circulation : the CircAdapt model [ J ]. American Journal of Physiology-Heart and Circulatory Physiology, 2005,88:H1943 - H1954.
  • 9Ku D N, Giddens D P, Zarins C K, et al. Pulsafile flow and altherosclerosis in the human carotid bifurcation J . Arteriosclerosis, 1985,5 (3) :293 - 302.
  • 10张铭,曾智.剪切应力与动脉粥样硬化[J].心脏杂志,2003,15(1):78-80. 被引量:2

二级参考文献33

  • 1程灏珠.实用内科学:第11版[M].上海:科学技术出版社,2000.1360-1361.
  • 2[1]Ku D N, Giddens D P, Zarins C K, et al. Pulsatile flow and atherosclerosis in the human carotid bifurcation [J]. Arteriosclerosis, 1990, 12 (5): 293-302.
  • 3[2]Taylor C A,Thomas J R,Hughes,Zarins C K. Finite element modeling of blood flow in arteries [J].Computer Methods in Applied Mechanics and Engineering, 1998,158:156-196.
  • 4[3]Bertolotti C, Deplano V, Fuseri J, et al. Numerical and experimental models of post-operative realistic flows in stenosed coronary bypasses [J].Journal of Biomechanics, 2001,34:1049-1064.
  • 5[4]Bertolotti C, Deplano V. Three-dimensional numerical simulations of flow through a stenosed coronary bypass [J]. Journal of Biomechanics, 2000,33: 1011-1022.
  • 6[5]Rene Botnar, Gerhard Rappitsch, Markus Beat Scheidegger, et al. Hemodynamics in the carotid artery bifurcation: a comparison between numerical simulation and in vitro MRI measurements [J].Journal of Biomechanics , 2000,33:137-144.
  • 7[6]Malek A M, Alper S L, Izumo S. Hemodynamic shear stress and its role in atherosclerosis [J].JAMA, 1999,282: 2035-2042.
  • 8[7]Moore J A, Steinman D A, Holdsworth D W, et al.Accuracy of computational hemodynamics in complex arterial geometries reconstructed from magnetic resonance imaging [J ]. Annals of Biomedical Engineering, 1999,27: 32-41.
  • 9[8]Anayiotos A S, Jones S A, Giddens D P, et al.Shear stress at a compliant model of the human carotid bifurcation[J]. ASME Jounal of Biomeche mical Engineering, 1994,116: 98-106.
  • 10[9]ZhaoSZ, Xu XY, HughesAD, et al. Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation [J].Journal of Biomechanics , 2000,22: 975-984.

共引文献29

同被引文献21

引证文献5

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部