22481例孕妇不规则抗体筛查的临床价值研究

Research of the clinical value about irregular antibody screening of 22481 pregnant women

目的通过对孕妇不规则抗体筛查发现具有临床意义的不规则抗体,研究孕产妇血型与血液输注相关性。方法采用凝胶柱法进行不规则抗体检测;对阳性标本进一步行抗体鉴定。结果 22 481名孕妇标本中,不规则抗体筛查阴性22 355例(99.44%),不规则抗体筛查阳性126例(0.56%)。MN血型系统50例,均为抗-M。Lewis血型系统27例,均为抗-Lea。Rh血型系统22例(占17.46%),其中抗-E 14例,抗-D 2例,联合抗体6例(抗-Ce 4例,抗-Ec 2例)。P血型系统2例,均为抗-P1。另外,检出抗-Tja1例,抗-HI 18例;未检出抗体特异性6例。结论应对每名孕妇进行红细胞ABO血型鉴定、RhD与RhE血型抗原检测以及不规则抗体筛查,才能确保选择相配合的血液制剂输注。

Objective To found significantly clinical irregular antibodies by screening the irregular antibody of preg- nant women. Methods Tests were done with micro-column gel agglutination assay for irregular antibody screening and i- dentification to positive samples. Results A total of 22 355 （99. 44% ） cases are irregular antibody screening negative and 126 cases （0. 56% ） are irregular antibody positive in an the 22 481 pregnant women. Among 126 positive cases,50 cases are anti- M, belonging to MN blood group system. 27 cases are anti-Le^a, belonging to Lewis blood group system. 22 cases be- long to the Rh blood group system,including 14 cases of anti-E,2 cases of anti-D,6 cases of combined antibody （anti-Ce 4 cases,anti-Ec 2 cases）. 2 cases are anti- P1, belonging to P blood group system. In addition,1 case is anti-Tj^a ;18 cases are anti-HI; the antibody specificity of 6 cases were not detected out. Conclusion In order to gain the precious rescue time, and choose the matching blood, we should carry on the ABO blood group identification, detection of RhD and RhE blood group antigens, and the screening of irregular antibody for every pregnant woman.