养阴生肌膜中冰片的包合工艺研究

Research on Inclusion Process of Borneol in YangYin ShengJi Membrane

目的:建立养阴生肌膜中冰片的β-环糊精最佳包合工艺。方法:以冰片的收得率和包合率为指标,采用正交实验方法,考察饱和水溶液法中冰片包合效果的主要影响因素。结果:冰片的β-CD包合最佳工艺是冰片与β-环糊精的比为1∶6,β-CD:H2O(g∶mL)为1:12,包合温度为45℃。结论:该包合工艺简单易行,切实可靠,适合生产。

Objective： To probe into the best technology for the inclusion ofborneol in YangYin ShengJi mem- brane with beta cyclodextrin（β-CD）. Methods： The yield rate and inclusion rate ofborneol were taken as the indexes, main factors influencing on bomeol inclusion were surveyed by saturated water aqua-solution method and orthogo- nal design. Results： The best inclusion technology of borneol with β-CD was： the ratio of borneol and β-CD=1：6, β-CD： H2O （g： mL） =1：12, the temperature was 45℃. Conclusion： The inclusion process is simple, feasible, reliable and suitable for the production.