人巴贝虫病研究进展

Research progress on human babesiosis

巴贝虫病是巴贝虫在红细胞内寄生导致的一种人畜共患寄生虫病.人巴贝虫病主要由田鼠巴贝虫（Babesia microti）、B.duncani、分歧巴贝虫（B.divergens）、B.venatorum等引起,病例呈世界性分布.其传播方式有蜱虫叮咬、输血及母婴传播等.患病症状与疟疾相似,典型的临床症状表现为发热、肌痛、贫血、血红蛋白尿、黄疸等,其严重程度主要取决于自身免疫状况和感染巴贝虫的种类.巴贝虫病常见的诊断方法为涂片染色法、动物接种法、血清学检测法以及分子生物学检测法.

Babesiosis, caused by infection with intraerythrocytic parasites of the genus Babesia,is an emerging zoonosis in human. The major species involved in human cases are Babesiamicroti,B. duncani, B. divergens ,B. venatorum. The three infection routes in human are tick biting, blood transfusion and vertical transmission. Clinical manifestations of babesiosis are similar to acute malaria, including fever, malaise, anemia, hemoglobinuria and jaundice. The severity of babesiosis depends primarily on the immune status of the patient and Babesia species. The major diagnostic techniques of babesiosis include Giemsa-stained exami- nation of thin blood smears, inoculation of susceptible animals with whole blood, serodiagnostic test and DNA amplification by PCR.