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Up-converting NaYF4:0.1%Tm^(3+), 20%Yb^(3+) nanoparticles as luminescent labels for deep-tissue optical imaging 被引量：5

Up-converting NaYF4:0.1%Tm^(3+), 20%Yb^(3+) nanoparticles as luminescent labels for deep-tissue optical imaging
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摘要 Optical imaging plays an important role in biomedical research being extremely useful for early detection, screening and image-guided therapy. Lanthanide-doped up-converting nanoparticles were ideally suited for bioimaging because they could be ex- cited in near infrared （NIR） and emit in NIR or visible （VIS）. Here, we compared lanthanide doped up-converting NaYF4 and organic fluorophores for application in deep-tissue imaging. For that purpose - tissue phantoms mimicking the natural properties of light scat- tering by living tissues were prepared. The studies allowed to quantitatively compare optical resolution of different fluorescent com- pounds, revealing that the NIR photoexcitation was favorable over conventional UV photoexcitation. Optical imaging plays an important role in biomedical research being extremely useful for early detection, screening and image-guided therapy. Lanthanide-doped up-converting nanoparticles were ideally suited for bioimaging because they could be ex- cited in near infrared （NIR） and emit in NIR or visible （VIS）. Here, we compared lanthanide doped up-converting NaYF4 and organic fluorophores for application in deep-tissue imaging. For that purpose - tissue phantoms mimicking the natural properties of light scat- tering by living tissues were prepared. The studies allowed to quantitatively compare optical resolution of different fluorescent com- pounds, revealing that the NIR photoexcitation was favorable over conventional UV photoexcitation.
作者 A. Gnach K. Prorok M. Misiak B. Cichy A. Bednarkiewicz
机构地区 Wroc?aw Research Centre EIT+ Institute of Immunology and Experimental Therapy Institute of Low Temp & Structure Research
出处 《Journal of Rare Earths》 SCIE EI CAS CSCD 2014年第3期207-212,共6页 稀土学报（英文版）
基金 Project supported by Wroclaw Research Centre EIT+within the project"The Application of Nanotechnology in Advanced Materials"-NanoMat(POIG.01.01.02-02-002/08)financed by the European Regional Development Fund(Operational Programme Innovative Economy,1.1.2)
关键词 upconverting nanoparticles deep tissue bioimaging lanthanide-doped NPs fluorescent materials rare earths upconverting nanoparticles deep tissue bioimaging lanthanide-doped NPs fluorescent materials rare earths
分类号 TN104.3 [电子电信—物理电子学]
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参考文献33

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Journal of Rare Earths
2014年 第3期

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