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幽门螺杆菌感染相关胃癌的细胞内信号转导通路研究现状 被引量：5

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摘要 世界上至少有50％的人口感染了幽门螺杆菌（Helicobacter,Pylori,HP）.胃癌是人类的第四大恶性肿瘤,其死亡率居世界第2位,约60％～80％的胃癌患者中可以检测到HP.胃癌的形成是一个多因素、多步骤复杂的过程,HP感染、宿主遗传因素和环境因素起共同作用,而HP感染可能为先导,从慢性活动性胃炎、慢性萎缩性胃炎、肠上皮化生和不典型性增生最终发展成胃癌的癌变模式已被国内外大多数学者认可,但HP感染导致胃癌发生的确切机制尚不清楚.细胞内信号转导是当前的研究热点之一,HP定植于胃黏膜后,可以激活多条信号通路参与细胞外向细胞内的信号传递,使上皮细胞发生一系列的病理生理改变,引起胃癌的发生.笔者查阅2007～2013年文献,对HP感染与胃癌相关的细胞内信号转导通路研究现状作一综述.
作者 刘爱群 葛莲英
机构地区 广西医科大学附属肿瘤医院内镜科
出处 《广西医科大学学报》 CAS 2014年第1期150-152,共3页 Journal of Guangxi Medical University
基金 广西卫生厅重点课题资助项目(No.2012092)
关键词 幽门螺杆菌 胃癌 信号转导通路
分类号 R735.2 [医药卫生—肿瘤]
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参考文献22

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二级参考文献15

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共引文献5

同被引文献25

引证文献5

二级引证文献33

广西医科大学学报
2014年 第1期

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