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羧酸甜菜碱甲基丙烯酸酯与DNA组装体系的耗散粒子动力学模拟

Dissipative Particle Dynamics(DPD) Simulation of Carboxybetaine Methacrylate(CBMA) and DNA Assembly System
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摘要 采用耗散粒子动力学模拟方法(DPD)研究了聚羧酸甜菜碱甲基丙烯酸酯(PCBMA)在不同浓度及pH下在水中的自组装与解组装情况,以及PCBMA与DNA的组装情况。模拟结果显示,不同浓度下,聚合物在水中依次形成球状、柱状、层状纳米粒子。pH下降时,DNA能被释放出来。 Using dissipative particle dynamics (DPD) simulation to study polycarboxy- betaine methacrylate (PCBMA) under different concentration and pH for self-assembly and solution of assembly under water, as well as the assembly of the PCBMA and DNA. According to the results, under different concentration, polymer form spherical, cylindrical and layered nanoparticles under water successfully. When pH falls, DNA can be released.
出处 《广东化工》 CAS 2014年第5期1-3,共3页 Guangdong Chemical Industry
基金 国家大学生创新性实验计划项目(201210561056)
关键词 耗散粒子动力学 自组装 阳离子聚合物 DNA DPD self-assembly: cationic polymer: DNA
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  • 1Carr L R,Jiang S.Mediating high levels of gene transfer without cytotoxicity via hydrolytic cationic ester polymers[J].Biomaterials,2010,31(14):4186-4193.
  • 2Zhou J,Liu J,Cheng C J,et al.Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery[J].Nature Materials,2012,11(1):82-90.
  • 3GrootRD,WarrenPB.JChemPhys,1997,107(11):4423.
  • 4Groot R D,Madden T J.J Chem Phys,1998,108(20):8713.
  • 5GrootRD,RaboneKL.BiophysJ,2001,81(2):725.
  • 6Maiti A,McGrother S.J Chem Phys,2004,120(3):1594.
  • 7Zhao Y,You L Y,Lu Z Y.Polymer,2009,50(22):5333.
  • 8解新安,丁年平,刘焕彬,郑璐丝,熊明洲.淀粉微球形成过程的介观模拟及实验[J].化学学报,2011,69(2):169-175. 被引量:6

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