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3-氨基喹啉衍生物的合成研究

Study on Synthesis of 3-Aminoquinoline Series
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摘要 氨基苯甲醛类化合物和硝基乙醛缩二甲醇Friedlnder环合得到硝基喹啉化合物,然后用二氯化锡还原得到3-氨基基喹啉衍生物。该反应条件温和,收率较高,路线简洁步骤简洁。 3-aminoquinoline series was synthesized from benzaldehyde series and nitroacetaldehydedimethyl acetal Friedl/inder reaction and reduction with Tin（II） chloride dihydrate. The new method might be a conventient route to 3-aminoquinoline series for its adventages of mild condition, high yield and succinct synthetic route.
作者 王小东
机构地区 苏州大学医学部药学院
出处 《广东化工》 CAS 2014年第6期10-11,共2页 Guangdong Chemical Industry
关键词 3-氨基喹啉 Friedl(a)nder环合 硝基乙醛缩二甲醇 氨基苯甲醛 3-aminoquinoline Friedlander nitroacetaldehydedimethylacetal benzaldehyde
分类号 TQ [化学工程]
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  • 1George Y', Ernest J, Monte 0, et al. 1,8- Naphthyridine Derivatives A New Class of Chemotherapeutic Agents[J]. J. Med. Chern, 1962, 5(5): 1063- 1065.
  • 2Koga H, Itoh A, Murayama S, et al. Structure-activity relationships of antibacterial 6,7 -and 7,8-disubstituted I-alkyl-I ,4- dihydro-4-oxoquinoline-3- carboxylicacids[J]. J. Med. Chern, 1980, 23(12): 1358-1363.
  • 3Gavriil M, Tsao C, Mandiyan S, et al. Specific IKKb inbibitor IV blocks streptonigrin-induced NF-kB activity and potentiates its cytotoxic effect on cancer cells[J]. Mol. Carcinogen, 2009, 48(8): 678-684.
  • 4Vargas M, Castelli M, Kouznetsov V, et al. In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers[J]. Bioorgan. Med. Chern. 2003, 11(7): 1531-1550.
  • 5Singh M, Singh M, Ablordeppey S. In vitro studies with liposomal cryptolepine[J]. Drug. Deve. Ind. Pharm. 1996, 22(4): 377-381.
  • 6Billker 0, Lindo V, Panico M, et al, Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito[J]. Nature, 1998 , 392(6673): 289-292.
  • 7Roma G, Braccio M, Grossi G, et al. 1,8-Naphthyridines IV. 9-Substituted N,N-dialkyl-5-(alkylamino or cycloalkylamino)[1,2,4) triazolo[4,3-a)[1,8) naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities[J]. Eur. J. Med. Chern, 2000, 35(11) : 1021-1035.
  • 8Chen Y, Fang K, Sheu J. et al. Synthesis and antibacterial evaluation of certain quinolone derivativcs[J]. J. Med. Chern, 2001, 44(14): 2374-2377.
  • 9Winstanley P. Chemotherapy for falciparum malaria: the armoury, the problems and the prospects, parasitol[J]. Today, 2000, 16(4): 146-153.
  • 10Drahl C. BIOCHEMISTRY: Studies advocate blocking cell-division protein essential metabolic pathway[J]. Chern. Eng. News, 2008, 86(38): 39-40.
广东化工
2014年 第6期

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