苯那普利减轻幼龄肾病大鼠蛋白尿的研究

Study on the effect of benazepril on reducing proteinuria in a nephrotic young rat model

目的 观察血管紧张素转换酶抑制剂苯那普利减轻幼龄肾病大鼠蛋白尿的作用。方法 对SD幼龄大鼠 (1个月龄 ,体重 10 0 g左右 )行单侧肾切除加阿霉素注射建立动物模型 ,术后即给予苯那普利 6mg·kg-1·d-1)治疗 12周 ,观察大鼠蛋白尿的变化。结果 于治疗的第 7、9、12周 ,苯那普利组 2 4h尿蛋白与同期模型组相比分别为 (7 34±4 36 )、(1 99± 1 2 4)、(5 18± 3 5 3)mg比 (14 44± 1 76 )、(17 48± 9 77)、(15 18± 4 71)mg (P均 <0 0 1)。 结论 在单侧肾切除后 1周注射阿霉素的幼龄SD肾病大鼠动物模型中 。

Objective To observe the effect of benazepril, an angiotensin converting enzyme inhibitor (ACEI) , on reducing proteinuria in a nephrotic young rat model of with massive proteinuria. Methods Animal model was made by uninephrectomy and following adriamycin (5 mg·kg -1 ) injected after one week through the tail vein in SD young rats (one month old, weighing 100 g±12 g). After uninephrectomy, the young rats were treated with benazepril 6 mg·kg -1 ·d -1 for 12 weeks. The proteinuria, the serum total protein and albumin and the serum cholesterol were measured at regular intervals. Results At 7, 9 and 12 weeks, proteinuria of benazepril group compared to one of model group is 7 34±4 36 vs 14 44±1 76, 1 99±1 24 vs 17 48±9 77 and 5 18±3 53 vs 15 18±4 71 mg·(24 h) -1 , P <0 01, respectively. Conclusion These results indicate that benazepril showed a reducing proteinuria property in a nephrotic animal model that was made by injecting adriamycin after one week of uninephrectomy in SD young rats.