S-腺苷蛋氨酸对原发性肝癌术后肝损伤的保护作用研究

Effect of S-adenosyl methionine on protection of postoperative liver damage in patients

目的探讨手术后静脉注射S-腺苷蛋氨酸制剂对原发性肝癌患者术后肝功能损伤的保护作用。方法选取2010—2012年本院收治的原发性肝癌患者60例,并随机分为试验组和对照组,每组30例。试验组术后给予S-腺苷蛋氨酸(思美泰)500mg静脉滴注,对照组术后给予还原型谷胱甘肽(阿拓莫兰)150mg静脉滴注。观察并比较2组术后第1、3、7天的肝功能情况。结果 2组患者的ALT、AST、LDH等指标均有不同程度的降低。在ALT含量方面,2组术后第1、3、7天比较差异均有统计学意义(P<0.05);在AST、LDH、ALP含量方面,2组术后第1、3、7天比较差异无统计学意义(P>0.05)。试验组术后ALT恢复速度显著优于对照组(P<0.05)。结论与常规还原型谷胱甘肽的保肝作用相比,肝切除术后应用S-腺苷蛋氨酸在ALT的含量和ALT恢复速度方面有着显著的优势,其他肝功能指标均无显著差异。

Objective To explore the effect of S-adenosyl methionine on protection of postoperative liver damage in patients with primary liver cancer. Methods 60 patients with primary liver cancer from 2010 to 2012 were randomly divided into trial group and control group,30 casesin each group. The trial group was treated with intravenous drip of 500 mg adenosyl methionine,while the control group was treated with intravenous drip of 150 mg glutathione. Liver functions at the time points of the first, third and seventh days after surgery were compared between two groups. Results Levelsof ALT,ASTand LDHreduced in both group. There were significant differences of ALT at the time points of the first, third and seventh days after surgery between two groups（P 0.05）. There were no significant differencesof AST, LDHand ALP at the time points of the first, third and seventh days after surgery between two groups（P 0.05）. Recovery rate of ALT in the trial group was significantly higher than that in the control group（P 0.05）. Conclusion Compared with glutathione, the effect of S-adenosyl methionine in the protection of liver function is significantly better, especially in the aspects of ALT content and ALT recovery rate.