艾司洛尔静脉全麻在减轻腹腔镜手术围术期应激反应中的效果观察

Effect observation of esmolol intravenous anesthesia on mitigation of perioperative stress reaction in patients with laparoscopic surgery

目的探讨艾司洛尔静脉全麻在减轻腹腔镜手术患者围术期应激反应中的效果。方法将120例患者随机分为实验组和对照组,每组60例。实验组给予静脉全麻+艾司洛尔,对照组给予静脉全麻+生理盐水。比较2组的血流动力学波动情况以及神经内分泌指标的变化情况。结果实验组气管插管时、气腹10min、术毕时的心率和血压均明显低于对照组(P<0.05);实验组气管插管时、气腹10min、术毕时的肾上腺素、去甲肾上腺素和皮质醇水平均明显低于对照组(P<0.05)。结论艾司洛尔能减轻围术期机体应激反应,降低发生心脑血管意外的风险。

Objective To explore the clinical effect of esmolol intravenous anesthesia on mitigation of perioperative stress reaction in patients with laparoscopic surgery. Methods 120 patients were randomly divided into experimental group（n= 60）and control group（n= 60）.The experimental group was treated with intravenous anesthesia and esmolol, while the control group was treated with intravenous anesthesia and saline. Changes of hemodynamics and neuroendocrine indicators were compared between two groups. Results Heart rate and mean arterial pressure at the time pointsof intubation,10 minutes after pneumoperitoneum and the end of operation in the experimental group were significantly lower than those in the control group（P 0.05）; the norepinephrine, epinephrine and cortisol at the time points of intubation,10 minutes after pneumoperitoneum and the end of operation in the experimental group were significantly lower than those in the control group（P 0.05）. Conclusion Esmolol is able to relieve perioperative stress reaction and reduce the risks of cardiovascular and cerebrovascular accidents.