清开灵中药制剂辅助头孢类药物治疗老年肺气肿的临床效果及其对炎性因子水平的影响

Clinical effect of Qingkailing preparation combined with cephalosporin drugs on treatment of elderly patients with emphysema and its influence on levels of inflammatory factors

目的探讨清开灵中药制剂辅助头孢类药物治疗老年肺气肿的临床疗效及其对炎性因子水平的影响。方法选取100例老年肺气肿合并感染患者作为研究对象,将其随机分为观察组和对照组,每组50例。对照组患者在常规疗法的基础上给予头孢呋辛钠静脉滴注治疗,观察组在对照组疗法的基础上加用清开灵中药制剂静脉滴注治疗,2组均以1周为一个疗程。2组患者在进行3个疗程的治疗后,比较2组患者的临床疗效、临床症状缓解时间、住院时间、体温恢复正常时间、药物不良反应情况及治疗前、后的血清中干扰素γ(INF-γ)和白介素-2(IL-2)的水平。结果观察组和对照组的临床有效率分别为98%(49/50)和66%(33/50),观察组的临床有效率显著高于对照组(P<0.05),而且观察组中疗效为完全缓解的患者比例显著高于对照组(P<0.05);观察组患者的临床症状缓解时间、住院时间和体温恢复正常时间均显著短于对照组(P<0.05);观察组和对照组患者的不良反应发生率分别为6%(3/50)和24%(12/50),观察组患者的不良反应发生率显著低于对照组(P<0.05),且观察组患者发生呕吐、胸痛、腹泻的比例显著低于对照组(P<0.05);2组患者的血清IFN-γ和IL-2水平均较同组治疗前显著降低(P<0.05),且观察组下降的幅度大于对照组(P<0.05)。结论清开灵中药制剂联合头孢类药物治疗老年肺气肿的疗效更佳,安全性更高,可显著降低血清炎性因子水平,缓解炎症反应,值得临床推广应用。

Objective To explore the clinical effect of Qingkailing preparation combined with cephalosporin drugs on the treatment of elderly patients with emphysema and its influence on levelsof inflammatory factors.Methods 100 elderly emphysema patients with infection were selected and randomly divided into observation group and control group,50 casesin each group. The control group was treated with intravenous drip of cefuroxime sodium on the basisof conventional therapy, while the observation group was treated with intravenous drip of Qingkailing preparation on the basis of the control group.After 3 courses of treatment, the clinical efficacy, the levels of serum inflammatory factors such as Interferon gamma（INF-γ）and interleukin-2（IL-2）, the remission time of clinical symptoms, the hospital stay, the temperature recovery time and adverse reactions were observed and analyzed between two groups.Results After treatment, the clinical effective rate in the observationgroup was 98%（49/50）, which was significantly higher than 66%（33/50）in the control group（P 0.05）, and the ratio of patients with complete remission in the observation group was significantly higher than that in the control group（P 0.05）. The remission time of clinical symptoms, the hospital stay and the temperature recovery time in the observation group were significantly shorter than those in the control group（P 0.05）. The incidence rate of adversereactionsin the observation group was 6%（3/ 5 0）,which was significantly lower than 2 4%（12/50）in the control group（P 0.05）, and ratios of the patients with vomiting, chest pain or diarrhea in the observation group were significantly lower than those in the control group（ P0.05）. After the treatment, the levels of serum IFN-γ and IL-2 in both groups decreased significantly（P 0.05）,and the improvementsof serum IFN-γ and IL-2 in the observation group were significantly better than those in the control group（P 0.05）.Conclusion Application of Qingkailing preparation combined with cephalosporin drugs in the treatment of the elderly patients with emphysema can significantly reduce levels of serum inflammatory factors and alleviate inflammatory reactions, so it is worthy of clinical application and popularization.