布地奈德联合盐酸氨溴索雾化吸入对小儿肺炎支原体感染所致慢性咳嗽的影响

Impacts of aerosol inhalation of budesonide combined with ambroxol hydrochloride in treating infants with chronic cough caused by pneumonia mycoplasma infection

目的探讨布地奈德联合盐酸氨溴索雾化吸入治疗小儿肺炎支原体感染所致慢性咳嗽的临床疗效。方法将84例因肺炎支原体感染引发的慢性咳嗽患儿随机分为观察组和对照组,每组42例。在阿奇霉素抗感染治疗基础上,对照组采用盐酸氨溴索雾化吸入,观察组采用布地奈德联合盐酸氨溴索雾化吸入。观察2组治疗前后外周静脉血嗜酸粒细胞(EOS)、免疫球蛋白E(IgE)及嗜酸粒细胞阳离子蛋白(ECP)水平的变化,以及治疗第1、3、5、7天时咳嗽症状积分情况,并比较临床疗效。随访期间,观察2组咳嗽缓解时间、消失时间及反复发作的次数。结果治疗第3、5、7天时,观察组患儿咳嗽症状积分明显低于对照组,而总有效率显著高于对照组。治疗后,2组外周静脉血EOS和ECP水平均较治疗前明显降低,而IgE水平明显升高。在咳嗽症状缓解及消失方面,观察组患儿所用时间较对照组明显缩短,且复发次数明显少于对照组。结论在抗感染基础上,布地奈德联合盐酸氨溴索雾化吸入治疗小儿肺炎支原体感染所致慢性咳嗽疗效显著,可明显缩短治疗时间,有效控制呼吸道反复感染。

Objective To discuss clinical effect of aerosol inhalation of budesonide combined with ambroxol hydrochloride in treating infants with chronic cough caused by pneumonia mycoplas- ma infection （PMI）. Methods Atotal of 84 infants caused by PMI were randomly divided into ob- servation group and control group with 42 patients in each group. The patients in control group were given azithmmycin anti - infectious treatment and aerosol inhalation of ambroxol hydrochloride while the observation group was added aerosol inhalation of budesonide on the basis of the control group. Eosinophil granulocyte （EOS）, immunoglobulin E （IgE） and eosinophil cationic protein （ECP） levels in both groups were observed before and after the treatment. The clinical effect and cough symptomatic scores on the first, the third, the fifth and the seventh days of treatment were compared. Meanwhile, the time of cough relieving and disappearance as well as recurrent within 3 months were recorded in the period of following up visits. Results Cough symptomatic scores were significantly lower, but overall response rate was higher in observation group than in the control group on the first, the third, the fifth and the seventh days of treatment. After treatment, ECP and EOS levels decreased obviously, and IgE increased evidently in both group. The time of cough relieving, disappear time and recurrent time within 3 months were obviously shorter in observation group than in control group. Conclusion Combination of Budesonide and ambroxol hydrochloride aerosol inhalation is remarkable in treating infants with chronic cough caused by MPI and are capa- ble of shortening treatment time and effectively controlling repeated infection of respiratory tract.