幽门螺杆菌感染与老年脑梗死和心肌梗死关系的研究

THE STUDY OF THE RELATIONS BETWEEN HELICOBACTER PYLORI INFECTION AND THE CEREBRAL INFARCTION AS WELL AS MYOCARDIAL INFARCTION IN ELDERLY PATIENTS

目的 通过比较脑梗死和心肌梗死患者与对照组血清幽门螺旋杆菌特异抗体 Ig G、Ig A、IGM的阳性率 ,探讨幽门螺旋杆菌与脑梗死和心肌梗死的关系。方法 老年脑梗死组 6 9例 ,老年心肌梗死 32例 ,对照组 42例。应用酶联免疫分析法分别测定三组Ig G、Ig A、IGM的阳性率。结果 脑梗死组幽门螺旋杆菌特异抗体 Ig G、Ig A、IGM阳性率分别为 82 .6 %、5 7.8%、19.5 % ,心肌梗死组为 87.6 %、6 0 .2 %、2 3.7% ;对照组则分别为 5 2 .4%、2 8.6 %、7.2 % ,与患病组相差有高度显著性 (P<0 .0 1)。患病组 Ig G和 /或 Ig A组合以及 Ig G和 /或 Ig A和 /或 IGM组合阳性率明显高于对照组 (P<0 .0 1)。患病组甘油三酯与 HP特异抗体 Ig GIg A呈明显正相关 (分别 P<0 .0 1)。结论 幽门螺旋杆菌感染与脑梗死和心肌梗死的发病密切相关 ;

Objective To find out the relations between helicobactor plyori infection and the cerebral infarction as well as myocardial infarction, and to explore their clinical significance. Methods 69 cases of cerebral infarction and 32 cases of myocardial infarction as well as 42 controls were selected for the study. Positive rates of IgG, IgA and IgM in the above three groups were detected by enzyme linked immunosorbent assay. Results Seropositive rates of IgG, IgA and IgM were 82.6%, 57.8% and 19.5% in cerebral infarction; 87.6%, 60.2% and 23.7% in myocardial infarction and 52.4%, 28.6% and 7.2% in the control group. A significant difference was shown between the study group and the control group (P<0.01). Trilyceride levels in both the cerebral and myocardial groups were higher than that in the control group (P<0.01). There was a significant correlation between H pylori and trilyceride (P<0.01). Conclusion Hpylori is significantly correlated with cerebral infarction and myocardial infarction in elderly patients. H pylori infection is probably another dangerous factor for ischemic cardiocascular and cerebrovascular diseases.