乳腺癌不同分子亚型与临床病理特征相关性分析

Correlation between Breast Cancer Molecular Subtype and the Clinicopathological Characteristics

目的研究乳腺癌患者分子分型情况及其与临床病理特征的相关性。方法随机选择2010年2月～2013年6月在泸州医学院附属医院明确诊断为乳腺癌病例共203例，根据其免疫组化进行分子分型，并观察其发病年龄、月经情况、组织学分级和TNM分期等指标，并进行统计分析。结果在203例研究对象中，Lumi—nal A型、Luminal B型、Basal-like型、HER-2过度表达型分别占52．2％、16．3％、16．3％、15．3％。各分子亚型之间在发病年龄与绝经情况方面没有统计学差异，但在原发肿瘤大小、淋巴结转移情况和组织学分级方面存在统计学差异，Luminal型较其它两种类型分期较早、分化程度较高。结论不同分子亚型的相关临床病理特征之间存在差异，这提示了不同分子亚型在预后及治疗上具有不同的特点，这为开展乳腺癌个体化治疗提供了有力的理论支持。

Objective To study the correlation between breast cancer molecular subtype and the clinicopathological characteristics. Methods 203 cases with breast cancer confirmed in the affiliated hospital to Luzhou Medical College from Feb., 2010 to June, 2013 were selected; the molecular typing was made based on the immunohistological study of the tumor slices; the onset age, menstruation, histological grading and TNM grading were observed and statistical analysis was performed. Results Out of the 203 cases, Luminal A subtype, Luminal B subtype, Basal-like subtype and HER-2 over-expression subtype took up 52.2%, 16.3%, 16.3% and 15.3% respectively; there was no statistical difference in onset age and menopause among all the molecular subtypes while a statistical difference in the size of primary tumors, lymph node metastasis and histological grading, Luminal type was of earlier staging and higher differentiation degree than the other two types. Conclusions The difference between various molecular subtypes and clinicopathological characteristics indicates the different molecular subtypes are of different characteristics in prognosis and therapy, which provides the theoretical support for individual therapy for patients with breast cancer..