血清胱抑素C与β_2微球蛋白在慢性肾病新分期中的检测与意义

Role of serum cystatin C and β_2-microglobumin in new staging of patients with chronicle kidney disease

目的探讨血清胱抑素C(Cys C)与β2微球蛋白(β2-MG)在慢性肾脏疾病(CKD)患者新分期中的临床诊断意义。方法选择解放军总医院2011年12月至2013年1月肾内科219例住院患者为研究对象,检测患者Cys C、β2-MG和其他肾功能指标,采用MDRD公式计算肾小球滤过率(eGFR)。分析Cys C、β2-MG与其他检测项目的相关性。结果 CKD不同分期患者Cys C和β2-MG指标差异有统计学意义(P<0.05)。随着eGFR下降,Cys C和β2-MG在CKD新分期中呈明显升高趋势,差异有统计学意义(P<0.05)。Cys C和β2-MG与肌酐、尿素氮有较好的相关性。结论 Cys C、β2-MG是用于评价CKD患者肾功能较好的实验室指标。

Objective To explore the clinical role of serum cystatin C andβ2-microglobumin in the new staging of patients with chronicle kidney disease .Methods Serum systatin C andβ2-microglobumin were analyzed in 219 pa-tients with chronic kidney disease and 35 healthy controls from December 2011 to January 2013 .The estimated glo-merular filtration rate （eGFR） was calculated using the modified Modification of Diet in Renal Disease （MDRD） e-quation .Results There were statistical significance between the patients with chronic kidney disease and healthy controls of the serum concentration of cystatin C and β2-microglobumin （P＆lt;0 .05） .The levels of serum cystatin C andβ2-microglobumin were increased with the decrease of the eGFR .It was statistical significant difference between the new stage of patients with chronic kidney disease for the serum cystatin C and β2-microglobumin （P＆lt;0 .05） .On linear regression ,the cystatin C andβ2-microglobumin were closely correlated to creatinine and urea .Conclusion Ser-um cystatin C andβ2-microglobumin might be sensitive indicators in judgment of renal damage of chronic kidney dis-ease and assessment of glomerular filtration rate .