不同类型肿瘤患者血清CA125检测结果分析

Analysis of CA125 levels in different types of cancer

目的探讨不同类型肿瘤患者及同地区健康者血清糖类抗原125(CA125)的水平,评价其在肿瘤疾病中的临床应用价值。方法对本地区307例肿瘤患者及94例健康者进行血清CA125检测,分析不同类型肿瘤患者和健康者间血清CA125水平的差异。结果健康者血清CA125水平较低,均值为11.0IU/mL。不同系统恶性肿瘤患者血清CA125水平明显上升,在同一系统不同类型恶性肿瘤患者间,血清CA125水平存在差异,呈现一定程度的表达水平异质性。结论 CA125在发病率较高的肺癌、肝癌、卵巢癌、子宫癌等恶性肿瘤中呈高水平表达,说明CA125检测具有较高的临床应用价值。但CA125在部分良性肿瘤中亦呈高表达,CA125临床应用中需重视对相关良性肿瘤的鉴别分析。

Objective To systematic evaluate the diagnostic value of serum carbohydrate antigen 125（CA125） for different types of cancer .Methods A total of 307 cancer patients and 94 health subjects from this area were re-cruited .Serum CA125 levels were detected and comparatively analyzed between patients and healthy subjects .Results Serum CA125 level in healthy subjects was relatively low ,with mean value of 11 .0 IU/mL .But in patients with malignancy ,serum CA125 levels were significant elevate ,and with diversity among patients with different types of tumor ,which indicated the serum CA125 expression might be with heterogeneous in cancer patients .Conclusion In lung cancer ,liver cancer ,ovarian cancer and uterine cancer ,which might be with high incidence ,serum levels of CA125 could be high ,that might indicate serum CA125 detection could be with important clinical application value . But high expression levels of serum CA125 could also be detected in some benign tumors ,which might indicate that pay more attention should be paid for the differential diagnosis of cancer in its clinical application .